Cumulative use of salivary markers with an adaptive design improves detection of periodontal disease over fixed biomarker thresholds

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Gursoy , U K , Pussinen , P J , Salomaa , V , Syrjalainen , S & Kononen , E 2018 , ' Cumulative use of salivary markers with an adaptive design improves detection of periodontal disease over fixed biomarker thresholds ' , Acta Odontologica Scandinavica , vol. 76 , no. 7 , pp. 493-496 . https://doi.org/10.1080/00016357.2018.1441436

Title: Cumulative use of salivary markers with an adaptive design improves detection of periodontal disease over fixed biomarker thresholds
Author: Gursoy, Ulvi Kahraman; Pussinen, Pirkko J.; Salomaa, Veikko; Syrjalainen, Sanna; Kononen, Eija
Contributor: University of Helsinki, Clinicum
Date: 2018
Language: eng
Number of pages: 4
Belongs to series: Acta Odontologica Scandinavica
ISSN: 0001-6357
URI: http://hdl.handle.net/10138/305973
Abstract: Objective: Aim was to analyze the diagnostic ability of cumulative risk score (CRS), which uses salivary levels of Porphyromonas gingivalis, interleukin (IL)-1 beta, and matrix metalloproteinase (MMP)-8 in an adaptive design, compared to previously reported thresholds of each marker alone. Materials and Methods: Oral and general health information of 463 participants were included in the analysis. Having the percentage of bleeding on probing (BOP) > 25%, having at least two sites with probing pocket depth (PPD) of 4-5 mm or having at least one tooth with alveolar bone loss (ABL) of at least 1/3 of the root length were accepted as outcome variables. Being above the salivary threshold concentrations of P. gingivalis, IL-1 beta, and MMP-8 and CRS values were used as explanatory variables. Receiver operating characteristics (ROC) producing an area under the curve (AUC) and multinomial regression analysis were used in statistical analysis. Results: CRS provided AUCs larger than any other tested biomarker threshold. Sensitivity and specificity of CRS for detecting clinical markers of periodontitis were acceptable, and a strong association was observed between the highest CRS score and having at least two sites with PPD of 4-5 mm. Conclusion: CRS brings additional power over fixed thresholds of single biomarkers in detecting periodontitis.
Subject: Biomarker
interleukin-1 beta
matrix metalloproteinase-8
periodontitis
porphyromonas gingivalis
saliva
MATRIX METALLOPROTEINASES
HOST
313 Dentistry
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