Natural Course of Frailty Components in People Who Develop Frailty Syndrome : Evidence From Two Cohort Studies

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http://hdl.handle.net/10138/306011

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Stenholm , S , Ferrucci , L , Vahtera , J , Hoogendijk , E O , Huisman , M , Pentti , J , Lindbohm , J V , Bandinelli , S , Guralnik , J M & Kivimäki , M 2019 , ' Natural Course of Frailty Components in People Who Develop Frailty Syndrome : Evidence From Two Cohort Studies ' , Journals of Gerontology. Series A: Biological Sciences and Medical Sciences , vol. 74 , no. 5 , pp. 667-674 . https://doi.org/10.1093/gerona/gly132

Title: Natural Course of Frailty Components in People Who Develop Frailty Syndrome : Evidence From Two Cohort Studies
Author: Stenholm, Sari; Ferrucci, Luigi; Vahtera, Jussi; Hoogendijk, Emiel O.; Huisman, Martijn; Pentti, Jaana; Lindbohm, Joni V.; Bandinelli, Stefania; Guralnik, Jack M.; Kivimäki, Mika
Contributor: University of Helsinki, Clinicum
University of Helsinki, HUS Neurocenter
University of Helsinki, Clinicum
Date: 2019-05
Language: eng
Number of pages: 8
Belongs to series: Journals of Gerontology. Series A: Biological Sciences and Medical Sciences
ISSN: 1079-5006
URI: http://hdl.handle.net/10138/306011
Abstract: Background: Frailty is an important geriatric syndrome, but little is known about its development in the years preceding onset of the syndrome. The aim of this study was to examine the progression of frailty and compare the trajectories of each frailty component prior to frailty onset. Methods: Repeat data were from two cohort studies: the Longitudinal Aging Study Amsterdam (n = 1440) with a 15-year follow-up and the InCHIANTI Study (n = 998) with a 9-year follow-up. Participants were classified as frail if they had > 3 frailty components (exhaustion, slowness, physical inactivity, weakness, and weight loss). Transitions between frailty components were examined with multistate modeling. Trajectories of frailty components were compared among persons who subsequently developed frailty to matched nonfrail persons by using mixed effects models. Results: The probabilities were 0.43, 0.40, and 0.36 for transitioning from 0 to 1 frailty component, from 1 component to 2 components, and from 2 components to 3-5 components (the frail state). The transition probability from frail to death was 0.13. Exhaustion separated frail and nonfrail groups already 9 years prior to onset of frailty (pooled risk ratio [RR] = 1.53, 95% confidence interval [CI] 1.04-2.24). Slowness (RR = 1.94, 95% CI 1.44-2.61), low activity (RR = 1.59, 95% CI 1.19-2.13), and weakness (RR = 1.39, 95% CI 1.10-1.76) separated frail and nonfrail groups 6 years prior to onset of frailty. The fifth frailty component, weight loss, separated frail and nonfrail groups only at the onset of frailty (RR = 3.36, 95% CI 2.76-4.08). Conclusions: Evidence from two cohort studies suggests that feelings of exhaustion tend to emerge early and weight loss near the onset of frailty syndrome.
Subject: Frailty
Exhaustion
Walking speed
Physical activity
Muscle strength
POISSON REGRESSION APPROACH
OLDER-ADULTS
WOMENS HEALTH
FATIGUE
DISABILITY
TRANSITIONS
MORTALITY
PREDICTION
FRACTURES
PHENOTYPE
3121 Internal medicine
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