Systematic review of analgesics and dexamethasone for post-tonsillectomy pain in adults

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Tolska , H K , Hamunen , K , Takala , A & Kontinen , V K 2019 , ' Systematic review of analgesics and dexamethasone for post-tonsillectomy pain in adults ' , British Journal of Anaesthesia , vol. 123 , no. 2 , pp. E397-E411 . https://doi.org/10.1016/j.bja.2019.04.063

Title: Systematic review of analgesics and dexamethasone for post-tonsillectomy pain in adults
Author: Tolska, H. K.; Hamunen, K.; Takala, A.; Kontinen, V. K.
Contributor organization: Anestesiologian yksikkö
HUS Perioperative, Intensive Care and Pain Medicine
University of Helsinki
Vesa Kontinen / Principal Investigator
University Management
Department of Pharmacology
Date: 2019-08
Language: eng
Number of pages: 15
Belongs to series: British Journal of Anaesthesia
ISSN: 0007-0912
DOI: https://doi.org/10.1016/j.bja.2019.04.063
URI: http://hdl.handle.net/10138/306021
Abstract: Background: Intense pain can last several days after tonsillectomy. It is often undertreated and improved analgesic strategies that can be safely used at home are needed. Methods: We conducted a systematic review and meta-analysis on the effectiveness of systemic medications used for post-tonsillectomy pain in adult and adolescent (13 yr old) patients. Studies were identified from PubMed, the Cochrane Library, and by hand searching reference lists from studies and review articles. Randomised, double-blind, placebo-controlled studies reporting on pain intensity or use of rescue analgesia were included. Results: Twenty-nine randomised controlled trials representing 1816 subjects met the inclusion criteria. Follow-up time was Conclusions: Single analgesics and dexamethasone provide only a weak to moderate effect for post-tonsillectomy pain on the day of operation and thus a multimodal analgesic strategy is recommended. Short follow-up times and clinical heterogeneity of studies limit the usefulness of results.
Subject: adolescent
adult
analgesics
dexamethasone
multimodal analgesia
postoperative pain
tonsillectomy
NONSTEROIDAL ANTIINFLAMMATORY DRUGS
POSTOPERATIVE PAIN
DOUBLE-BLIND
REDUCES PAIN
PARACETAMOL
DEXTROMETHORPHAN
KETOPROFEN
EFFICACY
RISK
GABAPENTIN/PREGABALIN
3126 Surgery, anesthesiology, intensive care, radiology
Peer reviewed: Yes
Usage restriction: openAccess
Self-archived version: publishedVersion


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