Burst statistics in an early biofilm quorum sensing model : the role of spatial colony-growth heterogeneity

Show full item record



Permalink

http://hdl.handle.net/10138/306038

Citation

Kindler , O , Pulkkinen , O , Cherstvy , A G & Metzler , R 2019 , ' Burst statistics in an early biofilm quorum sensing model : the role of spatial colony-growth heterogeneity ' , Scientific Reports , vol. 9 , 12077 . https://doi.org/10.1038/s41598-019-48525-2

Title: Burst statistics in an early biofilm quorum sensing model : the role of spatial colony-growth heterogeneity
Author: Kindler, Oliver; Pulkkinen, Otto; Cherstvy, Andrey G.; Metzler, Ralf
Contributor: University of Helsinki, Institute for Molecular Medicine Finland
Date: 2019-08-19
Language: eng
Number of pages: 19
Belongs to series: Scientific Reports
ISSN: 2045-2322
URI: http://hdl.handle.net/10138/306038
Abstract: Quorum-sensing bacteria in a growing colony of cells send out signalling molecules (so-called "autoinducers") and themselves sense the autoinducer concentration in their vicinity. Once-due to increased local cell density inside a "cluster" of the growing colony-the concentration of autoinducers exceeds a threshold value, cells in this clusters get "induced" into a communal, multi-cell biofilm-forming mode in a cluster-wide burst event. We analyse quantitatively the influence of spatial disorder, the local heterogeneity of the spatial distribution of cells in the colony, and additional physical parameters such as the autoinducer signal range on the induction dynamics of the cell colony. Spatial inhomogeneity with higher local cell concentrations in clusters leads to earlier but more localised induction events, while homogeneous distributions lead to comparatively delayed but more concerted induction of the cell colony, and, thus, a behaviour close to the mean-field dynamics. We quantify the induction dynamics with quantifiers such as the time series of induction events and burst sizes, the grouping into induction families, and the mean autoinducer concentration levels. Consequences for different scenarios of biofilm growth are discussed, providing possible cues for biofilm control in both health care and biotechnology.
Subject: BACTERIAL BIOFILMS
DIFFUSION
COMMUNICATION
BIODIVERSITY
COOPERATION
EXPRESSION
RESISTANCE
PROMOTES
SYSTEMS
SEARCH
1182 Biochemistry, cell and molecular biology
Rights:


Files in this item

Total number of downloads: Loading...

Files Size Format View
s41598_019_48525_2.pdf 5.114Mb PDF View/Open

This item appears in the following Collection(s)

Show full item record