L1TD1-a prognostic marker for colon cancer

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http://hdl.handle.net/10138/306056

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Chakroborty , D , Emani , M R , Klen , R , Bockelman , C , Hagström , J , Haglund , C , Ristimäki , A , Lahesmaa , R & Elo , L L 2019 , ' L1TD1-a prognostic marker for colon cancer ' , BMC Cancer , vol. 19 , 727 . https://doi.org/10.1186/s12885-019-5952-2

Title: L1TD1-a prognostic marker for colon cancer
Author: Chakroborty, Deepankar; Emani, Maheswara Reddy; Klen, Riku; Bockelman, Camilla; Hagström, Jaana; Haglund, Caj; Ristimäki, Ari; Lahesmaa, Riitta; Elo, Laura L.
Contributor: University of Helsinki, Clinicum
University of Helsinki, HUS Head and Neck Center
University of Helsinki, HUS Abdominal Center
University of Helsinki, Department of Pathology
Date: 2019-07-23
Language: eng
Number of pages: 9
Belongs to series: BMC Cancer
ISSN: 1471-2407
URI: http://hdl.handle.net/10138/306056
Abstract: BackgroundPrognostic markers specific to a particular cancer type can assist in the evaluation of survival probability of patients and help clinicians to assess the available treatment modalities.MethodsGene expression data was analyzed from three independent colon cancer microarray gene expression data sets (N=1052). Survival analysis was performed for the three data sets, stratified by the expression level of the LINE-1 type transposase domain containing 1 (L1TD1). Correlation analysis was performed to investigate the role of the interactome of L1TD1 in colon cancer patients.ResultsWe found L1TD1 as a novel positive prognostic marker for colon cancer. Increased expression of L1TD1 associated with longer disease-free survival in all the three data sets. Our results were in contrast to a previous study on medulloblastoma, where high expression of L1TD1 was linked with poor prognosis. Notably, in medulloblastoma L1TD1 was co-expressed with its interaction partners, whereas our analysis revealed lack of co-expression of L1TD1 with its interaction partners in colon cancer.ConclusionsOur results identify increased expression of L1TD1 as a prognostic marker predicting longer disease-free survival in colon cancer patients.
Subject: Human L1TD1 gene
Colon cancer
Prognostic factors
Biomarkers
Survival analysis
PEPTIDASE INHIBITOR CLADE
POOR-PROGNOSIS
TUMOR PROGRESSION
GENE-EXPRESSION
GASTRIC-CANCER
DOWN-REGULATION
PROTEIN L1TD1
MEMBER 1
METASTASIS
SUPPRESSES
3122 Cancers
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