Crystalline Wax Esters Regulate the Evaporation Resistance of Tear Film Lipid Layers Associated with Dry Eye Syndrome

Visa fullständig post



Permalänk

http://hdl.handle.net/10138/306068

Citation

Paananen , R O , Javanainen , M , Holopainen , J M & Vattulainen , I 2019 , ' Crystalline Wax Esters Regulate the Evaporation Resistance of Tear Film Lipid Layers Associated with Dry Eye Syndrome ' , Journal of Physical Chemistry Letters , vol. 10 , no. 14 , pp. 3893-3898 . https://doi.org/10.1021/acs.jpclett.9b01187

Titel: Crystalline Wax Esters Regulate the Evaporation Resistance of Tear Film Lipid Layers Associated with Dry Eye Syndrome
Författare: Paananen, Riku O.; Javanainen, Matti; Holopainen, Juha M.; Vattulainen, Ilpo
Medarbetare: University of Helsinki, Department of Ophthalmology and Otorhinolaryngology
University of Helsinki, Department of Physics
University of Helsinki, HUS Head and Neck Center
University of Helsinki, Department of Physics
Datum: 2019-07-18
Språk: eng
Sidantal: 11
Tillhör serie: Journal of Physical Chemistry Letters
ISSN: 1948-7185
Permanenta länken (URI): http://hdl.handle.net/10138/306068
Abstrakt: Dry eye syndrome (DES), one of the most common ophthalmological diseases, is typically caused by excessive evaporation of tear fluid from the ocular surface. Excessive evaporation is linked to impaired function of the tear film lipid layer (TFLL) that covers the aqueous tear film. The principles of the evaporation resistance of the TFLL have remained unknown, however. We combined atomistic simulations with Brewster angle microscopy and surface potential experiments to explore the organization and evaporation resistance of films composed of wax esters, one of the main components of the TFLL. The results provide evidence that the evaporation resistance of the TFLL is based on crystalline-state layers of wax esters and that the evaporation rate is determined by defects in the TFLL and its coverage on the ocular surface. On the basis of the results, uncovering the nonequilibrium spreading and crystallization of TFLL films has potential to reveal new means of treating DES.
Subject: FORCE-FIELD
PERMEATION
WATER
TEMPERATURE
MEIBUM
OXYGEN
116 Chemical sciences
114 Physical sciences
Licens:


Filer under denna titel

Totalt antal nerladdningar: Laddar...

Filer Storlek Format Granska
acs.jpclett.9b01187.pdf 3.660Mb PDF Granska/Öppna

Detta dokument registreras i samling:

Visa fullständig post