Crystalline Wax Esters Regulate the Evaporation Resistance of Tear Film Lipid Layers Associated with Dry Eye Syndrome

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dc.contributor University of Helsinki, Department of Ophthalmology and Otorhinolaryngology en
dc.contributor University of Helsinki, Department of Physics en
dc.contributor University of Helsinki, HUS Head and Neck Center en
dc.contributor University of Helsinki, Department of Physics en
dc.contributor.author Paananen, Riku O.
dc.contributor.author Javanainen, Matti
dc.contributor.author Holopainen, Juha M.
dc.contributor.author Vattulainen, Ilpo
dc.date.accessioned 2019-10-16T12:02:02Z
dc.date.available 2019-10-16T12:02:02Z
dc.date.issued 2019-07-18
dc.identifier.citation Paananen , R O , Javanainen , M , Holopainen , J M & Vattulainen , I 2019 , ' Crystalline Wax Esters Regulate the Evaporation Resistance of Tear Film Lipid Layers Associated with Dry Eye Syndrome ' , Journal of Physical Chemistry Letters , vol. 10 , no. 14 , pp. 3893-3898 . https://doi.org/10.1021/acs.jpclett.9b01187 en
dc.identifier.issn 1948-7185
dc.identifier.other PURE: 127462096
dc.identifier.other PURE UUID: 20dcfe95-7aa2-4270-832f-16d0ca97078c
dc.identifier.other WOS: 000476694300011
dc.identifier.other ORCID: /0000-0001-7408-3214/work/63351241
dc.identifier.other ORCID: /0000-0003-4858-364X/work/63351538
dc.identifier.uri http://hdl.handle.net/10138/306068
dc.description.abstract Dry eye syndrome (DES), one of the most common ophthalmological diseases, is typically caused by excessive evaporation of tear fluid from the ocular surface. Excessive evaporation is linked to impaired function of the tear film lipid layer (TFLL) that covers the aqueous tear film. The principles of the evaporation resistance of the TFLL have remained unknown, however. We combined atomistic simulations with Brewster angle microscopy and surface potential experiments to explore the organization and evaporation resistance of films composed of wax esters, one of the main components of the TFLL. The results provide evidence that the evaporation resistance of the TFLL is based on crystalline-state layers of wax esters and that the evaporation rate is determined by defects in the TFLL and its coverage on the ocular surface. On the basis of the results, uncovering the nonequilibrium spreading and crystallization of TFLL films has potential to reveal new means of treating DES. en
dc.format.extent 11
dc.language.iso eng
dc.relation.ispartof Journal of Physical Chemistry Letters
dc.rights en
dc.subject FORCE-FIELD en
dc.subject PERMEATION en
dc.subject WATER en
dc.subject TEMPERATURE en
dc.subject MEIBUM en
dc.subject OXYGEN en
dc.subject 116 Chemical sciences en
dc.subject 114 Physical sciences en
dc.title Crystalline Wax Esters Regulate the Evaporation Resistance of Tear Film Lipid Layers Associated with Dry Eye Syndrome en
dc.type Article
dc.description.version Peer reviewed
dc.identifier.doi https://doi.org/10.1021/acs.jpclett.9b01187
dc.type.uri info:eu-repo/semantics/other
dc.type.uri info:eu-repo/semantics/publishedVersion
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