Association between Body Mass Index and Gastric Cancer Risk According to Effect Modification by Helicobacter pylori Infection

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http://hdl.handle.net/10138/306078

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Jang , J , Cho , E-J , Hwang , Y , Weiderpass , E , Ahn , C , Choi , J , Chang , S-H , Shin , H-R , Lim , M K , Yoo , K-Y & Park , S K 2019 , ' Association between Body Mass Index and Gastric Cancer Risk According to Effect Modification by Helicobacter pylori Infection ' , Breast Cancer Research and Treatment , vol. 51 , no. 3 , pp. 1107-1116 . https://doi.org/10.4143/crt.2018.182

Title: Association between Body Mass Index and Gastric Cancer Risk According to Effect Modification by Helicobacter pylori Infection
Author: Jang, Jieun; Cho, Eun-Jung; Hwang, Yunji; Weiderpass, Elisabete; Ahn, Choonghyun; Choi, Jeoungbin; Chang, Soung-Hoon; Shin, Hai-Rim; Lim, Min Kyung; Yoo, Keun-Young; Park, Sue K.
Contributor: University of Helsinki, Department of Medical and Clinical Genetics
Date: 2019-07
Language: eng
Number of pages: 10
Belongs to series: Breast Cancer Research and Treatment
ISSN: 1598-2998
URI: http://hdl.handle.net/10138/306078
Abstract: Purpose Few studies investigated roles of body mass index (BMI) on gastric cancer (GC) risk according to Helicobacter pylori infection status. This study was conducted to evaluate associations between BMI and GC risk with consideration of H. pylori infection information. Materials and Methods We performed a case-cohort study (n=2,458) that consists of a subcohort (n=2,193 including 67 GC incident cases) randomly selected from the Korean Multicenter Cancer Cohort (KMCC) and 265 incident GC cases outside of the subcohort. H. pylori infection was assessed using an immunoblot assay. GC risk according to BMI was evaluated by calculating hazard ratios (HRs) and their 95% confidence intervals (95% CIs) using weighted Cox hazard regression model. Results Increased GC risk in lower BMI group (= 25 kg/m(2)) showed non-significantly increased GC risk (HR, 10.82; 95% CI, 1.25 to 93.60 and HR, 11.33; 95% CI, 1.13 to 113.66, respectively). However, these U-shaped associations between BMI and GC risk were not observed in the group who had ever been infected by H. pylori. Conclusion This study suggests the U-shaped associations between BMI and GC risk, especially in subjects who had never been infected by H. pylori.
Subject: Stomach neoplasms
Body mass index
Helicobacter pylori
Cohort studies
Case-cohort
Effect modification
POPULATION
ESOPHAGEAL
OBESITY
PATTERNS
CARDIA
COHORT
3122 Cancers
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