Association between Body Mass Index and Gastric Cancer Risk According to Effect Modification by Helicobacter pylori Infection

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dc.contributor.author Jang, Jieun
dc.contributor.author Cho, Eun-Jung
dc.contributor.author Hwang, Yunji
dc.contributor.author Weiderpass, Elisabete
dc.contributor.author Ahn, Choonghyun
dc.contributor.author Choi, Jeoungbin
dc.contributor.author Chang, Soung-Hoon
dc.contributor.author Shin, Hai-Rim
dc.contributor.author Lim, Min Kyung
dc.contributor.author Yoo, Keun-Young
dc.contributor.author Park, Sue K.
dc.date.accessioned 2019-10-17T09:48:01Z
dc.date.available 2019-10-17T09:48:01Z
dc.date.issued 2019-07
dc.identifier.citation Jang , J , Cho , E-J , Hwang , Y , Weiderpass , E , Ahn , C , Choi , J , Chang , S-H , Shin , H-R , Lim , M K , Yoo , K-Y & Park , S K 2019 , ' Association between Body Mass Index and Gastric Cancer Risk According to Effect Modification by Helicobacter pylori Infection ' , Breast Cancer Research and Treatment , vol. 51 , no. 3 , pp. 1107-1116 . https://doi.org/10.4143/crt.2018.182
dc.identifier.other PURE: 127483662
dc.identifier.other PURE UUID: e41c85df-3d26-4406-baf6-421bcba95081
dc.identifier.other WOS: 000476707300026
dc.identifier.uri http://hdl.handle.net/10138/306078
dc.description.abstract Purpose Few studies investigated roles of body mass index (BMI) on gastric cancer (GC) risk according to Helicobacter pylori infection status. This study was conducted to evaluate associations between BMI and GC risk with consideration of H. pylori infection information. Materials and Methods We performed a case-cohort study (n=2,458) that consists of a subcohort (n=2,193 including 67 GC incident cases) randomly selected from the Korean Multicenter Cancer Cohort (KMCC) and 265 incident GC cases outside of the subcohort. H. pylori infection was assessed using an immunoblot assay. GC risk according to BMI was evaluated by calculating hazard ratios (HRs) and their 95% confidence intervals (95% CIs) using weighted Cox hazard regression model. Results Increased GC risk in lower BMI group (= 25 kg/m(2)) showed non-significantly increased GC risk (HR, 10.82; 95% CI, 1.25 to 93.60 and HR, 11.33; 95% CI, 1.13 to 113.66, respectively). However, these U-shaped associations between BMI and GC risk were not observed in the group who had ever been infected by H. pylori. Conclusion This study suggests the U-shaped associations between BMI and GC risk, especially in subjects who had never been infected by H. pylori. en
dc.format.extent 10
dc.language.iso eng
dc.relation.ispartof Breast Cancer Research and Treatment
dc.rights cc_by_nc
dc.rights.uri info:eu-repo/semantics/openAccess
dc.subject Stomach neoplasms
dc.subject Body mass index
dc.subject Helicobacter pylori
dc.subject Cohort studies
dc.subject Case-cohort
dc.subject Effect modification
dc.subject POPULATION
dc.subject ESOPHAGEAL
dc.subject OBESITY
dc.subject PATTERNS
dc.subject CARDIA
dc.subject COHORT
dc.subject 3122 Cancers
dc.title Association between Body Mass Index and Gastric Cancer Risk According to Effect Modification by Helicobacter pylori Infection en
dc.type Article
dc.contributor.organization Department of Medical and Clinical Genetics
dc.contributor.organization University of Helsinki
dc.contributor.organization Faculty of Medicine
dc.description.reviewstatus Peer reviewed
dc.relation.doi https://doi.org/10.4143/crt.2018.182
dc.relation.issn 1598-2998
dc.rights.accesslevel openAccess
dc.type.version publishedVersion

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