Hypertensive Disorders of Pregnancy and DNA Methylation in Newborns Findings From the Pregnancy and Childhood Epigenetics Consortium

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Kazmi , N , Sharp , G C , Reese , S E , Vehmeijer , F O , Lahti , J , Page , C M , Zhang , W , Rifas-Shiman , S L , Rezwan , F I , Simpkin , A J , Burrows , K , Richardson , T G , Ferreira , D L S , Fraser , A , Harmon , Q E , Zhao , S , Jaddoe , V W V , Czamara , D , Binder , E B , Magnus , M C , Haberg , S E , Nystad , W , Nohr , E A , Starling , A P , Kechris , K J , Yang , I V , DeMeo , D L , Litonjua , A A , Baccarelli , A , Oken , E , Holloway , J W , Karmaus , W , Arshad , S H , Dabelea , D , Sorensen , T I A , Laivuori , H , Räikkönen , K , Felix , J F , London , S J , Hivert , M-F , Gaunt , T R , Lawlor , D A & Relton , C L 2019 , ' Hypertensive Disorders of Pregnancy and DNA Methylation in Newborns Findings From the Pregnancy and Childhood Epigenetics Consortium ' , Hypertension , vol. 74 , no. 2 , pp. 375-383 . https://doi.org/10.1161/HYPERTENSIONAHA.119.12634

Title: Hypertensive Disorders of Pregnancy and DNA Methylation in Newborns Findings From the Pregnancy and Childhood Epigenetics Consortium
Author: Kazmi, Nabila; Sharp, Gemma C.; Reese, Sarah E.; Vehmeijer, Florianne O.; Lahti, Jari; Page, Christian M.; Zhang, Weiming; Rifas-Shiman, Sheryl L.; Rezwan, Faisal I.; Simpkin, Andrew J.; Burrows, Kimberley; Richardson, Tom G.; Ferreira, Diana L. Santos; Fraser, Abigail; Harmon, Quaker E.; Zhao, Shanshan; Jaddoe, Vincent W. V.; Czamara, Darina; Binder, Elisabeth B.; Magnus, Maria C.; Haberg, Siri E.; Nystad, Wenche; Nohr, Ellen A.; Starling, Anne P.; Kechris, Katerina J.; Yang, Ivana V.; DeMeo, Dawn L.; Litonjua, Augusto A.; Baccarelli, Andrea; Oken, Emily; Holloway, John W.; Karmaus, Wilfried; Arshad, Syed H.; Dabelea, Dana; Sorensen, Thorkild I. A.; Laivuori, Hannele; Räikkönen, Katri; Felix, Janine F.; London, Stephanie J.; Hivert, Marie-France; Gaunt, Tom R.; Lawlor, Debbie A.; Relton, Caroline L.
Contributor organization: Doctoral Programme in Cognition, Learning, Instruction and Communication
Department of Psychology and Logopedics
Developmental Psychology Research Group
Helsinki Collegium for Advanced Studies
University of Helsinki
HUS Gynecology and Obstetrics
Genomics of Neurological and Neuropsychiatric Disorders
Institute for Molecular Medicine Finland
Pregnancy and Genes
University Management
Department of Medical and Clinical Genetics
Helsinki Institute of Life Science HiLIFE
Faculty of Medicine
Date: 2019-08
Language: eng
Number of pages: 9
Belongs to series: Hypertension
ISSN: 0194-911X
DOI: https://doi.org/10.1161/HYPERTENSIONAHA.119.12634
URI: http://hdl.handle.net/10138/306341
Abstract: Hypertensive disorders of pregnancy (HDP) are associated with low birth weight, shorter gestational age, and increased risk of maternal and offspring cardiovascular diseases later in life. The mechanisms involved are poorly understood, but epigenetic regulation of gene expression may play a part. We performed meta-analyses in the Pregnancy and Childhood Epigenetics Consortium to test the association between either maternal HDP (10 cohorts; n=5242 [cases=476]) or preeclampsia (3 cohorts; n=2219 [cases=135]) and epigenome-wide DNA methylation in cord blood using the Illumina HumanMethylation450 BeadChip. In models adjusted for confounders, and with Bonferroni correction, HDP and preeclampsia were associated with DNA methylation at 43 and 26 CpG sites, respectively. HDP was associated with higher methylation at 27 (63%) of the 43 sites, and across all 43 sites, the mean absolute difference in methylation was between 0.6% and 2.6%. Epigenome-wide associations of HDP with offspring DNA methylation were modestly consistent with the equivalent epigenome-wide associations of preeclampsia with offspring DNA methylation (R-2=0.26). In longitudinal analyses conducted in 1 study (n=108 HDP cases; 550 controls), there were similar changes in DNA methylation in offspring of those with and without HDP up to adolescence. Pathway analysis suggested that genes located at/near HDP-associated sites may be involved in developmental, embryogenesis, or neurological pathways. HDP is associated with offspring DNA methylation with potential relevance to development.
Subject: cardiovascular diseases
DNA methylation
gestational age
3121 General medicine, internal medicine and other clinical medicine
Peer reviewed: Yes
Rights: cc_by
Usage restriction: openAccess
Self-archived version: publishedVersion

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