Haem iron intake and risk of lung cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort

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Ward , H A , Whitman , J , Muller , D C , Johansson , M , Jakszyn , P , Weiderpass , E , Palli , D , Fanidi , A , Vermeulen , R , Tjonneland , A , Hansen , L , Dahm , C C , Overvad , K , Severi , G , Boutron-Ruault , M-C , Affret , A , Kaaks , R , Fortner , R , Boeing , H , Trichopoulou , A , La Vecchia , C , Kotanidou , A , Berrino , F , Krogh , V , Tumino , R , Ricceri , F , Panico , S , Bueno-de-Mesquita , H B , Peeters , P H , Nost , T H , Sandanger , T M , Ramon Quiros , J , Agudo , A , Rodriguez-Barranco , M , Larranaga , N , Maria Huerta , J , Ardanaz , E , Drake , I , Brunnstrom , H , Johansson , M , Grankvist , K , Travis , R C , Freisling , H , Stepien , M , Merritt , M A , Riboli , E & Cross , A J 2019 , ' Haem iron intake and risk of lung cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort ' , European Journal of Clinical Nutrition , vol. 73 , no. 8 , pp. 1122-1132 . https://doi.org/10.1038/s41430-018-0271-2

Title: Haem iron intake and risk of lung cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort
Author: Ward, Heather A.; Whitman, Julia; Muller, David C.; Johansson, Mattias; Jakszyn, Paula; Weiderpass, Elisabete; Palli, Domenico; Fanidi, Anouar; Vermeulen, Roel; Tjonneland, Anne; Hansen, Louise; Dahm, Christina C.; Overvad, Kim; Severi, Gianluca; Boutron-Ruault, Marie-Christine; Affret, Aurelie; Kaaks, Rudolf; Fortner, Renee; Boeing, Heiner; Trichopoulou, Antonia; La Vecchia, Carlo; Kotanidou, Anastasia; Berrino, Franco; Krogh, Vittorio; Tumino, Rosario; Ricceri, Fulvio; Panico, Salvatore; Bueno-de-Mesquita, H. Bas; Peeters, Petra H.; Nost, Therese Haugdahl; Sandanger, Torkjel M.; Ramon Quiros, Jose; Agudo, Antonio; Rodriguez-Barranco, Miguel; Larranaga, Nerea; Maria Huerta, Jose; Ardanaz, Eva; Drake, Isabel; Brunnstrom, Hans; Johansson, Mikael; Grankvist, Kjell; Travis, Ruth C.; Freisling, Heinz; Stepien, Magdalena; Merritt, Melissa A.; Riboli, Elio; Cross, Amanda J.
Contributor organization: Department of Medical and Clinical Genetics
University of Helsinki
Faculty of Medicine
Date: 2019-08
Language: eng
Number of pages: 11
Belongs to series: European Journal of Clinical Nutrition
ISSN: 0954-3007
DOI: https://doi.org/10.1038/s41430-018-0271-2
URI: http://hdl.handle.net/10138/306344
Abstract: Background Epidemiological studies suggest that haem iron, which is found predominantly in red meat and increases endogenous formation of carcinogenic N-nitroso compounds, may be positively associated with lung cancer. The objective was to examine the relationship between haem iron intake and lung cancer risk using detailed smoking history data and serum cotinine to control for potential confounding. Methods In the European Prospective Investigation into Cancer and Nutrition (EPIC), 416,746 individuals from 10 countries completed demographic and dietary questionnaires at recruitment. Cox proportional hazards models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for incident lung cancer (n = 3731) risk relative to haem iron, non-haem iron, and total dietary iron intake. A corresponding analysis was conducted among a nested subset of 800 lung cancer cases and 1489 matched controls for whom serum cotinine was available. Results Haem iron was associated with lung cancer risk, including after adjustment for details of smoking history (time since quitting, number of cigarettes per day): as a continuous variable (HR per 0.3 mg/1000 kcal 1.03, 95% CI 1.00-1.07), and in the highest versus lowest quintile (HR 1.16, 95% CI 1.02-1.32; trend across quintiles: P = 0.035). In contrast, non-haem iron intake was related inversely with lung cancer risk; however, this association attenuated after adjustment for smoking history. Additional adjustment for serum cotinine did not considerably alter the associations detected in the nested case-control subset. Conclusions Greater haem iron intake may be modestly associated with lung cancer risk.
3143 Nutrition
3111 Biomedicine
Peer reviewed: Yes
Usage restriction: openAccess
Self-archived version: publishedVersion

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