Diagnosing Celiac Disease : Towards Wide-Scale Screening and Serology-Based Criteria?

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http://hdl.handle.net/10138/306397

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Popp , A , Kivela , L , Fuchs , V & Kurppa , K 2019 , ' Diagnosing Celiac Disease : Towards Wide-Scale Screening and Serology-Based Criteria? ' , Gastroenterology Research and Practice , vol. 2019 , 2916024 . https://doi.org/10.1155/2019/2916024

Title: Diagnosing Celiac Disease : Towards Wide-Scale Screening and Serology-Based Criteria?
Author: Popp, Alina; Kivela, Laura; Fuchs, Valma; Kurppa, Kalle
Contributor: University of Helsinki, Children's Hospital
Date: 2019-08-06
Language: eng
Number of pages: 10
Belongs to series: Gastroenterology Research and Practice
ISSN: 1687-6121
URI: http://hdl.handle.net/10138/306397
Abstract: Celiac disease is one of the most common food-related chronic disorders in children. Unfortunately, this multifaceted disease is challenging to recognize and remains markedly underdiagnosed. Screening of either known at-risk groups or even the whole population could increase the suboptimal diagnostic yield substantially. Many recent guidelines recommend screening of at least selected risk groups, but more wide-scale screening remains controversial. The increasing prevalence of celiac disease and the development of autoantibody assays have also led to a gradual shift in the diagnostics towards less invasive serology-based criteria in a subgroup of symptomatic children. The main open questions concern whether these criteria are applicable to all countries and clinical settings, as well as to adult patients. On the other hand, widening screening and the mistaken practice of initiating a gluten-free diet before the appropriate exclusion of celiac disease increase the number of borderline seropositive cases, which may also challenge the classical histopathological diagnostics. Sophisticated diagnostic methods and a deeper understanding of the natural history of early developing celiac disease may prove useful in these circumstances.
Subject: GLUTEN-FREE DIET
QUALITY-OF-LIFE
BONE-MINERAL DENSITY
BOWEL VILLOUS ATROPHY
TISSUE TRANSGLUTAMINASE
PRIMARY-CARE
LONG-TERM
FOLLOW-UP
PEDIATRIC GASTROENTEROLOGY
GASTROINTESTINAL SYMPTOMS
3121 General medicine, internal medicine and other clinical medicine
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