Phylogeography of Puumala orthohantavirus in Europe

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http://hdl.handle.net/10138/306431

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Castel , G , Chevenet , F , Razzauti , M , Murri , S , Marianneau , P , Cosson , J-F , Tordo , N & Plyusnin , A 2019 , ' Phylogeography of Puumala orthohantavirus in Europe ' , Viruses-Basel , vol. 11 , no. 8 , 679 . https://doi.org/10.3390/v11080679

Title: Phylogeography of Puumala orthohantavirus in Europe
Author: Castel, Guillaume; Chevenet, Francois; Razzauti, Maria; Murri, Severine; Marianneau, Philippe; Cosson, Jean-Francois; Tordo, Noel; Plyusnin, Alexander
Contributor: University of Helsinki, Infection Biology Research Program
Date: 2019-08
Language: eng
Number of pages: 16
Belongs to series: Viruses-Basel
ISSN: 1999-4915
URI: http://hdl.handle.net/10138/306431
Abstract: Puumala virus is an RNA virus hosted by the bank vole (Myodes glareolus) and is today present in most European countries. Whilst it is generally accepted that hantaviruses have been tightly co-evolving with their hosts, Puumala virus (PUUV) evolutionary history is still controversial and so far has not been studied at the whole European level. This study attempts to reconstruct the phylogeographical spread of modern PUUV throughout Europe during the last postglacial period in the light of an upgraded dataset of complete PUUV small (S) segment sequences and by using most recent computational approaches. Taking advantage of the knowledge on the past migrations of its host, we identified at least three potential independent dispersal routes of PUUV during postglacial recolonization of Europe by the bank vole. From the Alpe-Adrian region (Balkan, Austria, and Hungary) to Western European countries (Germany, France, Belgium, and Netherland), and South Scandinavia. From the vicinity of Carpathian Mountains to the Baltic countries and to Poland, Russia, and Finland. The dissemination towards Denmark and North Scandinavia is more hypothetical and probably involved several independent streams from south and north Fennoscandia.
Subject: puumala orthohantavirus
phylogeography
co-evolution
bank vole (myodes glareolus)
VOLES MICROTUS-AGRESTIS
BANK VOLE
MYODES-GLAREOLUS
POSTGLACIAL COLONIZATION
MOLECULAR EVOLUTION
MITOCHONDRIAL-DNA
GENETIC-VARIATION
HANTAVIRUS INFECTIONS
PHYLOGENETIC ANALYSIS
DEMOGRAPHIC HISTORY
3111 Biomedicine
1183 Plant biology, microbiology, virology
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