PIM-related kinases selectively regulate olfactory sensations in C. elegans

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Kalichamy , K S , Ikkala , K , Pörsti , J , Santio , N M , Tuomaala , J , Jha , S , Holmberg , C & Koskinen , P J 2019 , ' PIM-related kinases selectively regulate olfactory sensations in C. elegans ' , eNeuro , vol. 6 , no. 4 , UNSP ENEURO.0003-19.2019 . https://doi.org/10.1523/ENEURO.0003-19.2019

Titel: PIM-related kinases selectively regulate olfactory sensations in C. elegans
Författare: Kalichamy, Karunambigai S.; Ikkala, Kaisa; Pörsti, Jonna; Santio, Niina M.; Tuomaala, Joel; Jha, Sweta; Holmberg, Carina; Koskinen, Päivi J.
Upphovmannens organisation: CAN-PRO - Translational Cancer Medicine Program
Research Programs Unit
University of Helsinki
University Management
Datum: 2019
Språk: eng
Sidantal: 42
Tillhör serie: eNeuro
ISSN: 2373-2822
DOI: https://doi.org/10.1523/ENEURO.0003-19.2019
Permanenta länken (URI): http://hdl.handle.net/10138/306487
Abstrakt: The mammalian PIM family of serine/threonine kinases regulate several cellular functions, such as cell survival and motility. Since PIM expression is observed in sensory organs, such as olfactory epithelium, we now wanted to explore the physiological roles of PIM kinascs there. As our model organism, we used the Caenorhabditis elegans nematodes, which express two PIM-related kinases, PRK-1 and PRK-2. We demonstrated PRKs to be true PIM orthologs with similar substrate specificity as well as sensitivity to PIM-inhibitory compounds. When we analysed the effects of pan-PIM inhibitors on C. elegans sensory functions, we observed that PRK activity is selectively required to support olfactory sensations to volatile repellents and attractants sensed by AWB and AWC(ON) neurons, respectively, but is dispensable for gustatory sensations. Analyses of prk-deficient mutant strains confirmed these findings and suggested that PRK-1, but not PRK-2 is responsible for the observed effects on olfaction. This regulatory role of PRK-1 is further supported by its observed expression in the head and tail neurons, including AWB and AWC neurons. Based on the evolutionary conservation of NM-related kinases, our data may have implications in regulation of also mammalian olfaction.
3112 Neurosciences
3124 Neurology and psychiatry
3111 Biomedicine
Referentgranskad: Ja
Licens: cc_by
Användningsbegränsning: openAccess
Parallelpublicerad version: publishedVersion

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