Vitamin D was not associated with survival or cerebrospinal fluid cathelicidin levels in children with bacterial meningitis

Show full item record



Permalink

http://hdl.handle.net/10138/306641

Citation

Savonius , O , Pelkonen , T , Roine , I , Viljakainen , H , Andersson , S , Fernandez , J , Peltola , H & Helve , O 2018 , ' Vitamin D was not associated with survival or cerebrospinal fluid cathelicidin levels in children with bacterial meningitis ' , Acta Paediatrica , vol. 107 , no. 12 , pp. 2131-2136 . https://doi.org/10.1111/apa.14393

Title: Vitamin D was not associated with survival or cerebrospinal fluid cathelicidin levels in children with bacterial meningitis
Author: Savonius, Okko; Pelkonen, Tuula; Roine, Irmeli; Viljakainen, Heli; Andersson, Sture; Fernandez, Josefina; Peltola, Heikki; Helve, Otto
Contributor organization: Children's Hospital
Clinicum
University of Helsinki
HUS Children and Adolescents
Lastentautien yksikkö
Date: 2018-12
Language: eng
Number of pages: 6
Belongs to series: Acta Paediatrica
ISSN: 0803-5253
DOI: https://doi.org/10.1111/apa.14393
URI: http://hdl.handle.net/10138/306641
Abstract: Aim Vitamin D deficiency impairs the immunological system and has been associated with worse outcomes of infectious diseases, but its role in bacterial meningitis remains unknown. We investigated whether serum 25-hydroxyvitamin D concentrations related to disease outcomes and to cerebrospinal fluid (CSF) cathelicidin concentrations in childhood bacterial meningitis. Methods Results All consecutively enrolled patients in a clinical trial on childhood bacterial meningitis in Latin America in 1996-2003 were considered, and 142 children, with a median age of seven months who had a confirmed bacterial aetiology and frozen serum available for further analyses, were included in this study. Serum 25-hydroxyvitamin D concentrations were determined with a chemiluminescence immunoassay analyser, while CSF cathelicidin was measured by enzyme-linked immunosorbent assay. The median serum 25-hydroxyvitamin D concentration was 96 (range 19-251) nmol/L. No relationship was found with patient survival, but children with any neurological sequelae had lower serum 25-hydroxyvitamin D levels than children without sequelae. Serum 25-hydroxyvitamin D was unrelated to cathelicidin concentrations in CSF. Conclusion Although serum 25-hydroxyvitamin D in children with bacterial meningitis was not associated with survival or CSF cathelicidin concentrations, its relationship with more detailed disease outcomes warrants further study.
Subject: Bacterial meningitis
Cathelicidin
Immunity
Neurological sequelae
Vitamin D deficiency
PLACEBO-CONTROLLED TRIAL
D DEFICIENCY
25-HYDROXYVITAMIN D
TRACT-INFECTION
DOUBLE-BLIND
D-RECEPTOR
TUBERCULOSIS
POPULATION
PEPTIDE
CELLS
3123 Gynaecology and paediatrics
Peer reviewed: Yes
Usage restriction: openAccess
Self-archived version: publishedVersion


Files in this item

Total number of downloads: Loading...

Files Size Format View
Savonius_et_al_2018_Acta_Paediatrica.pdf 155.3Kb PDF View/Open

This item appears in the following Collection(s)

Show full item record