Vitamin D was not associated with survival or cerebrospinal fluid cathelicidin levels in children with bacterial meningitis

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Savonius , O , Pelkonen , T , Roine , I , Viljakainen , H , Andersson , S , Fernandez , J , Peltola , H & Helve , O 2018 , ' Vitamin D was not associated with survival or cerebrospinal fluid cathelicidin levels in children with bacterial meningitis ' , Acta Paediatrica , vol. 107 , no. 12 , pp. 2131-2136 . https://doi.org/10.1111/apa.14393

Title: Vitamin D was not associated with survival or cerebrospinal fluid cathelicidin levels in children with bacterial meningitis
Author: Savonius, Okko; Pelkonen, Tuula; Roine, Irmeli; Viljakainen, Heli; Andersson, Sture; Fernandez, Josefina; Peltola, Heikki; Helve, Otto
Contributor: University of Helsinki, Children's Hospital
University of Helsinki, Children's Hospital
University of Helsinki, HUS Children and Adolescents
University of Helsinki, HUS Children and Adolescents
University of Helsinki, Children's Hospital
University of Helsinki, Children's Hospital
Date: 2018-12
Language: eng
Number of pages: 6
Belongs to series: Acta Paediatrica
ISSN: 0803-5253
URI: http://hdl.handle.net/10138/306641
Abstract: Aim Vitamin D deficiency impairs the immunological system and has been associated with worse outcomes of infectious diseases, but its role in bacterial meningitis remains unknown. We investigated whether serum 25-hydroxyvitamin D concentrations related to disease outcomes and to cerebrospinal fluid (CSF) cathelicidin concentrations in childhood bacterial meningitis. Methods Results All consecutively enrolled patients in a clinical trial on childhood bacterial meningitis in Latin America in 1996-2003 were considered, and 142 children, with a median age of seven months who had a confirmed bacterial aetiology and frozen serum available for further analyses, were included in this study. Serum 25-hydroxyvitamin D concentrations were determined with a chemiluminescence immunoassay analyser, while CSF cathelicidin was measured by enzyme-linked immunosorbent assay. The median serum 25-hydroxyvitamin D concentration was 96 (range 19-251) nmol/L. No relationship was found with patient survival, but children with any neurological sequelae had lower serum 25-hydroxyvitamin D levels than children without sequelae. Serum 25-hydroxyvitamin D was unrelated to cathelicidin concentrations in CSF. Conclusion Although serum 25-hydroxyvitamin D in children with bacterial meningitis was not associated with survival or CSF cathelicidin concentrations, its relationship with more detailed disease outcomes warrants further study.
Subject: Bacterial meningitis
Cathelicidin
Immunity
Neurological sequelae
Vitamin D deficiency
PLACEBO-CONTROLLED TRIAL
D DEFICIENCY
25-HYDROXYVITAMIN D
TRACT-INFECTION
DOUBLE-BLIND
D-RECEPTOR
TUBERCULOSIS
POPULATION
PEPTIDE
CELLS
3123 Gynaecology and paediatrics
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