Microbiome and type 1 diabetes

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http://hdl.handle.net/10138/306689

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Siljander , H , Honkanen , J & Knip , M 2019 , ' Microbiome and type 1 diabetes ' , EBioMedicine , vol. 46 , pp. 512-521 . https://doi.org/10.1016/j.ebiom.2019.06.031

Title: Microbiome and type 1 diabetes
Author: Siljander, Heli; Honkanen, Jarno; Knip, Mikael
Contributor: University of Helsinki, HUS Children and Adolescents
University of Helsinki, CAMM - Research Program for Clinical and Molecular Metabolism
University of Helsinki, HUS Children and Adolescents
Date: 2019-08
Language: eng
Number of pages: 10
Belongs to series: EBioMedicine
ISSN: 2352-3964
URI: http://hdl.handle.net/10138/306689
Abstract: The steep increase in the incidence of type 1 diabetes (T1D), in the Western world after World War II, cannot be explained solely by genetic factors but implies that this rise must be due to crucial interactions between predisposing genes and environmental changes. Three parallel phenomena in early childhood – the dynamic development of the immune system, maturation of the gut microbiome, and the appearance of the first T1D-associated autoantibodies – raise the question whether these phenomena might reflect causative relationships. Plenty of novel data on the role of the microbiome in the development of T1D has been published over recent years and this review summarizes recent findings regarding the associations between islet autoimmunity, T1D, and the intestinal microbiota.
Subject: 3121 General medicine, internal medicine and other clinical medicine
Type 1 diabetes
Microbiota
Mycobiota
Virome
Dysbiosis
GLYCEMIC CONTROL
FECAL MICROBIOTA
EARLY-CHILDHOOD
FUNGAL MICROBIOTA
CHILDREN
HUMAN GUT MICROBIOME
HOST GENETICS
HIGH-RISK
ISLET AUTOIMMUNITY
INTESTINAL PERMEABILITY
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