Insulin exposure mitigates the increase of arterial stiffness in patients with type 2 diabetes and albuminuria: an exploratory analysis

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Gordin , D , Saraheimo , M , Tuomikangas , J , Soro-Paavonen , A , Forsblom , C , Paavonen , K , Steckel-Hamann , B , Harjutsalo , V , Nicolaou , L , Pavo , I , Koivisto , V & Groop , P-H 2019 , ' Insulin exposure mitigates the increase of arterial stiffness in patients with type 2 diabetes and albuminuria: an exploratory analysis ' , Acta Diabetologica , vol. 56 , no. 11 , pp. 1169-1175 . https://doi.org/10.1007/s00592-019-01351-4

Title: Insulin exposure mitigates the increase of arterial stiffness in patients with type 2 diabetes and albuminuria: an exploratory analysis
Author: Gordin, Daniel; Saraheimo, Markku; Tuomikangas, Jaana; Soro-Paavonen, Aino; Forsblom, Carol; Paavonen, Karri; Steckel-Hamann, Birgit; Harjutsalo, Valma; Nicolaou, Loizos; Pavo, Imre; Koivisto, Veikko; Groop, Per-Henrik
Contributor: University of Helsinki, HUS Abdominal Center
University of Helsinki, HUS Abdominal Center
University of Helsinki, Clinicum
University of Helsinki, University Management
University of Helsinki, Nefrologian yksikkö
University of Helsinki, Department of Medicine
University of Helsinki, Research Programs Unit
University of Helsinki, HUS Abdominal Center
Date: 2019-11
Language: eng
Number of pages: 7
Belongs to series: Acta Diabetologica
ISSN: 1432-5233
URI: http://hdl.handle.net/10138/306732
Abstract: Aims Insulin possesses both vasodilatory and sympathomimetic activities. The aim was to examine the relationship between changes in insulin exposure and arterial stiffness in type 2 diabetes (T2D). Methods Patients with T2D with (n = 22) or without (n = 24) albuminuria, and non-diabetic controls (n = 25) were randomized to a crossover study having a breakfast with or without pre-meal rapid-acting insulin. Pulse wave velocity (PWV) was measured at 30 min before and at 60-min intervals up to 240 min after the breakfast. Results At baseline, both postprandial aortic (p = 0.022) and brachial (p = 0.011) PWV were higher in individuals with T2D than in healthy controls irrespective of the presence of albuminuria. In patients with albuminuria, weight-adjusted insulin dose correlated inversely with the excursion of the aortic (r = - 0.412, p = 0.006) and brachial (r = - 0.372; p = 0.014) PWV. Similarly, circulating endogenous insulin concentrations correlated inversely with the aortic (r = - 0.347, p = 0.026) and brachial (r = - 0.622, p =
Subject: 3121 General medicine, internal medicine and other clinical medicine
Type 2 Diabetes
Pulse wave velocity
Arterial stiffness
Insulin resistance
Albuminuria
Diabetic nephropathy
Diabetic kidney disease
VASODILATION
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