Mode of delivery in hemophilia : vaginal delivery and Cesarean section carry similar risks for intracranial hemorrhages and other major bleeds

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PedNet Haemophilia Res Fdn , Andersson , N G , Chalmers , E A , Kenet , G , Mäkipernaa , A & Chambost , H 2019 , ' Mode of delivery in hemophilia : vaginal delivery and Cesarean section carry similar risks for intracranial hemorrhages and other major bleeds ' , Haematologica , vol. 104 , no. 10 , pp. 2100-2106 . https://doi.org/10.3324/haematol.2018.209619

Title: Mode of delivery in hemophilia : vaginal delivery and Cesarean section carry similar risks for intracranial hemorrhages and other major bleeds
Author: PedNet Haemophilia Res Fdn; Andersson, Nadine G.; Chalmers, Elizabeth A.; Kenet, G.; Mäkipernaa, Anne; Chambost, Herve
Contributor: University of Helsinki, HUS Comprehensive Cancer Center
Date: 2019-09-30
Language: eng
Number of pages: 7
Belongs to series: Haematologica
ISSN: 0390-6078
URI: http://hdl.handle.net/10138/306753
Abstract: The optimal mode of delivery for a pregnant hemophilia carrier is still a matter of debate. The aim of the study was to determine the incidence of intracranial hemorrhage and other major bleeds in neonates with moderate and severe hemophilia in relationship to mode of delivery and known family history. A total of 926 neonates, 786 with severe and 140 with moderate hemophilia were included in this PedNet multicenter study. Vaginal delivery was performed in 68.3% (n=633) and Cesarean section in 31.6% (n=293). Twenty intracranial hemorrhages (2.2%) and 44 other major bleeds (4.8%) occurred. Intracranial hemorrhages occurred in 2.4% of neonates following vaginal delivery compared to 1.7% after Cesarean section (P=not significant); other major bleeds occurred in 4.2% born by vaginal delivery and in 5.8% after Cesarean section (P=not significant). Further analysis of subgroups (n=813) identified vaginal delivery with instruments being a significant risk factor for both intracranial hemorrhages and major bleeds (Relative Risk: 4.78-7.39; P
Subject: AFFECTED INFANT
NEWBORNS
PREVALENCE
DIAGNOSIS
MORTALITY
LIFE
3121 General medicine, internal medicine and other clinical medicine
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