Mode of delivery in hemophilia : vaginal delivery and Cesarean section carry similar risks for intracranial hemorrhages and other major bleeds

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dc.contributor University of Helsinki, HUS Comprehensive Cancer Center en
dc.contributor.author PedNet Haemophilia Res Fdn
dc.contributor.author Andersson, Nadine G.
dc.contributor.author Chalmers, Elizabeth A.
dc.contributor.author Kenet, G.
dc.contributor.author Mäkipernaa, Anne
dc.contributor.author Chambost, Herve
dc.date.accessioned 2019-11-05T12:28:01Z
dc.date.available 2019-11-05T12:28:01Z
dc.date.issued 2019-09-30
dc.identifier.citation PedNet Haemophilia Res Fdn , Andersson , N G , Chalmers , E A , Kenet , G , Mäkipernaa , A & Chambost , H 2019 , ' Mode of delivery in hemophilia : vaginal delivery and Cesarean section carry similar risks for intracranial hemorrhages and other major bleeds ' , Haematologica , vol. 104 , no. 10 , pp. 2100-2106 . https://doi.org/10.3324/haematol.2018.209619 en
dc.identifier.issn 0390-6078
dc.identifier.other PURE: 127916078
dc.identifier.other PURE UUID: 5ac947cc-9e64-4ce9-b15e-fce9e3de9181
dc.identifier.other WOS: 000488513600037
dc.identifier.uri http://hdl.handle.net/10138/306753
dc.description.abstract The optimal mode of delivery for a pregnant hemophilia carrier is still a matter of debate. The aim of the study was to determine the incidence of intracranial hemorrhage and other major bleeds in neonates with moderate and severe hemophilia in relationship to mode of delivery and known family history. A total of 926 neonates, 786 with severe and 140 with moderate hemophilia were included in this PedNet multicenter study. Vaginal delivery was performed in 68.3% (n=633) and Cesarean section in 31.6% (n=293). Twenty intracranial hemorrhages (2.2%) and 44 other major bleeds (4.8%) occurred. Intracranial hemorrhages occurred in 2.4% of neonates following vaginal delivery compared to 1.7% after Cesarean section (P=not significant); other major bleeds occurred in 4.2% born by vaginal delivery and in 5.8% after Cesarean section (P=not significant). Further analysis of subgroups (n=813) identified vaginal delivery with instruments being a significant risk factor for both intracranial hemorrhages and major bleeds (Relative Risk: 4.78-7.39; P en
dc.format.extent 7
dc.language.iso eng
dc.relation.ispartof Haematologica
dc.rights en
dc.subject AFFECTED INFANT en
dc.subject NEWBORNS en
dc.subject PREVALENCE en
dc.subject DIAGNOSIS en
dc.subject MORTALITY en
dc.subject LIFE en
dc.subject 3121 General medicine, internal medicine and other clinical medicine en
dc.title Mode of delivery in hemophilia : vaginal delivery and Cesarean section carry similar risks for intracranial hemorrhages and other major bleeds en
dc.type Article
dc.description.version Peer reviewed
dc.identifier.doi https://doi.org/10.3324/haematol.2018.209619
dc.type.uri info:eu-repo/semantics/other
dc.type.uri info:eu-repo/semantics/publishedVersion
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