Dietary carbohydrate intake and cardio-metabolic risk factors in type 1 diabetes

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The FinnDiane Study Group , Ahola , A J , Forsblom , C , Harjutsalo , V & Groop , P-H 2019 , ' Dietary carbohydrate intake and cardio-metabolic risk factors in type 1 diabetes ' , Diabetes Research and Clinical Practice , vol. 155 , 107818 .

Title: Dietary carbohydrate intake and cardio-metabolic risk factors in type 1 diabetes
Author: The FinnDiane Study Group; Ahola, Aila J.; Forsblom, Carol; Harjutsalo, Valma; Groop, Per-Henrik
Contributor organization: Diabetes and Obesity Research Program
Staff Services
HUS Abdominal Center
Department of Medicine
Nefrologian yksikkö
CAMM - Research Program for Clinical and Molecular Metabolism
Research Programs Unit
University of Helsinki
Faculty of Medicine
Per Henrik Groop / Principal Investigator
University Management
Date: 2019-09
Language: eng
Number of pages: 8
Belongs to series: Diabetes Research and Clinical Practice
ISSN: 0168-8227
Abstract: Aims Low-carbohydrate diet (LCD) has gained interest among individuals with diabetes as a means to manage glycaemia. We investigated the adherence to LCD in the Finnish Diabetic Nephropathy Study and whether carbohydrate restriction is associated with cardio-metabolic risk factors. Methods Cross-sectional data were available from 902 individuals with type 1 diabetes (44% men, age 47±13 years). Dietary data were collected twice with a 3-day diet record. Mean of the measurements was used. Carbohydrate intake 253 g/day or >48 E%). In the whole population, carbohydrate-to-fat ratio was calculated and its association with health variables was investigated. Results Higher carbohydrate-to-fat ratio was associated with higher blood glucose variability, higher blood pressure, lower HDL cholesterol concentration, and in men with lower waist-to-hip ratio. LCD adherence (n=69) was associated with lower BMI (25.6 vs. 27.8 kg/m2, p=0.030), lower variability of blood glucose measurements (0.38 vs. 0.45 mmol/l, p=0.030), and lower diastolic blood pressure (74 vs. 79 mmHg, p=0.048). Men reporting LCD had higher total (5.1 vs. 4.0 mmol/l, p=0.007) and non-HDL cholesterol (3.4 vs. 2.7 mmol/l, p=0.021). Women with LCD had higher HDL-cholesterol concentration (1.9 vs. 1.5 mmol/l, p=0.014). Conclusions Reduced blood glucose variability, related to LCD, could have clinical relevance to individuals with type 1 diabetes.
Subject: 3121 General medicine, internal medicine and other clinical medicine
Cardio-metabolic risk factors
Glycaemic control
Low-carbohydrate diet
Type 1 diabetes
Peer reviewed: Yes
Rights: cc_by_nc_nd
Usage restriction: openAccess
Self-archived version: acceptedVersion

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