Prognostic value of blood and lymphatic vessel markers in tongue cancer : A Systematic Review

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http://hdl.handle.net/10138/306776

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Almahmoudi , R , Kasanen , M , Sieviläinen , M , Salem , A , Pirinen , M , Salo , T & Al-Samadi , A 2019 , ' Prognostic value of blood and lymphatic vessel markers in tongue cancer : A Systematic Review ' , Cancer Science , vol. 110 , no. 11 , pp. 3424-3433 . https://doi.org/10.1111/cas.14189

Titel: Prognostic value of blood and lymphatic vessel markers in tongue cancer : A Systematic Review
Författare: Almahmoudi, Rabeia; Kasanen, Merimaija; Sieviläinen, Meri; Salem, Abdelhakim; Pirinen, Matti; Salo, Tuula; Al-Samadi, Ahmed
Upphovmannens organisation: Department of Oral and Maxillofacial Diseases
TRIMM - Translational Immunology Research Program
University of Helsinki
Clinicum
Research Programs Unit
Centre of Excellence in Complex Disease Genetics
Statistical and population genetics
Department of Mathematics and Statistics
Institute for Molecular Medicine Finland
Biostatistics Helsinki
Department of Public Health
Helsinki Institute of Life Science HiLIFE
HUSLAB
Datum: 2019-11
Språk: eng
Sidantal: 10
Tillhör serie: Cancer Science
ISSN: 1347-9032
DOI: https://doi.org/10.1111/cas.14189
Permanenta länken (URI): http://hdl.handle.net/10138/306776
Abstrakt: Tongue squamous cell carcinoma (TSCC) has a poor prognosis due to its early metastasis via blood and lymphatic vessels. We performed a systematic review to investigate the prognostic significance of blood microvessel density (MVD) and lymphatic vessel density (LVD) in TSCC patients. We conducted a systematic search in Ovid Medline, Scopus, and Cochrane libraries. All studies that evaluated the prognostic significance of MVD/LVD markers in TSCC were systematically retrieved. Our results showed that MVD/LVD markers, CD31, CD34, CD105, factor VIII, LYVE‐1, and D2‐40 were evaluated in TSCC patients until 28 June 2018. Six out of 13 studies reported markers that were associated with poor prognosis in TSCC. Two out of three studies suggested that a high number of D2‐40+ vessels predicated low overall survival (OS); the third study reported that the ratio of D2‐40+ over factor VIII+ vessels is associated with low OS. Most of the other markers had controversial results for prognostication. We found higher expression of MVD/LVD markers were commonly, but not always, associated with shorter survival in TSCC patients. It is therefore not currently possible to recommend implementation of these markers as reliable prognosticators in clinical practice. More studies (especially for D2‐40) with larger patient cohorts are needed.
Subject: ANGIOGENESIS
ASSOCIATION
CD105 EXPRESSION
DENSITY
HEAD
HEPATOCELLULAR-CARCINOMA
LYMPHANGIOGENESIS
NODE METASTASIS
SQUAMOUS-CELL CARCINOMA
VASCULAR INVASION
biomarker
blood microvessel density
lymphatic vessel density
prognosis
tongue squamous cell carcinoma
3122 Cancers
111 Mathematics
Referentgranskad: Ja
Licens: cc_by_nc
Användningsbegränsning: openAccess
Parallelpublicerad version: publishedVersion


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