Prognostic value of blood and lymphatic vessel markers in tongue cancer : A Systematic Review

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dc.contributor.author Almahmoudi, Rabeia
dc.contributor.author Kasanen, Merimaija
dc.contributor.author Sieviläinen, Meri
dc.contributor.author Salem, Abdelhakim
dc.contributor.author Pirinen, Matti
dc.contributor.author Salo, Tuula
dc.contributor.author Al-Samadi, Ahmed
dc.date.accessioned 2019-11-06T13:32:01Z
dc.date.available 2019-11-06T13:32:01Z
dc.date.issued 2019-11
dc.identifier.citation Almahmoudi , R , Kasanen , M , Sieviläinen , M , Salem , A , Pirinen , M , Salo , T & Al-Samadi , A 2019 , ' Prognostic value of blood and lymphatic vessel markers in tongue cancer : A Systematic Review ' , Cancer Science , vol. 110 , no. 11 , pp. 3424-3433 . https://doi.org/10.1111/cas.14189
dc.identifier.other PURE: 127173839
dc.identifier.other PURE UUID: 0f653b0d-3bfd-46d3-8364-e59993a7078c
dc.identifier.other WOS: 000488200300001
dc.identifier.other ORCID: /0000-0001-6039-0088/work/64323708
dc.identifier.other ORCID: /0000-0002-1664-1350/work/64323979
dc.identifier.other ORCID: /0000-0002-9455-3823/work/64324496
dc.identifier.other ORCID: /0000-0002-7286-8031/work/90909066
dc.identifier.uri http://hdl.handle.net/10138/306776
dc.description.abstract Tongue squamous cell carcinoma (TSCC) has a poor prognosis due to its early metastasis via blood and lymphatic vessels. We performed a systematic review to investigate the prognostic significance of blood microvessel density (MVD) and lymphatic vessel density (LVD) in TSCC patients. We conducted a systematic search in Ovid Medline, Scopus, and Cochrane libraries. All studies that evaluated the prognostic significance of MVD/LVD markers in TSCC were systematically retrieved. Our results showed that MVD/LVD markers, CD31, CD34, CD105, factor VIII, LYVE‐1, and D2‐40 were evaluated in TSCC patients until 28 June 2018. Six out of 13 studies reported markers that were associated with poor prognosis in TSCC. Two out of three studies suggested that a high number of D2‐40+ vessels predicated low overall survival (OS); the third study reported that the ratio of D2‐40+ over factor VIII+ vessels is associated with low OS. Most of the other markers had controversial results for prognostication. We found higher expression of MVD/LVD markers were commonly, but not always, associated with shorter survival in TSCC patients. It is therefore not currently possible to recommend implementation of these markers as reliable prognosticators in clinical practice. More studies (especially for D2‐40) with larger patient cohorts are needed. en
dc.format.extent 10
dc.language.iso eng
dc.relation.ispartof Cancer Science
dc.rights cc_by_nc
dc.rights.uri info:eu-repo/semantics/openAccess
dc.subject ANGIOGENESIS
dc.subject ASSOCIATION
dc.subject CD105 EXPRESSION
dc.subject DENSITY
dc.subject HEAD
dc.subject HEPATOCELLULAR-CARCINOMA
dc.subject LYMPHANGIOGENESIS
dc.subject NODE METASTASIS
dc.subject SQUAMOUS-CELL CARCINOMA
dc.subject VASCULAR INVASION
dc.subject biomarker
dc.subject blood microvessel density
dc.subject lymphatic vessel density
dc.subject prognosis
dc.subject tongue squamous cell carcinoma
dc.subject 3122 Cancers
dc.subject 111 Mathematics
dc.title Prognostic value of blood and lymphatic vessel markers in tongue cancer : A Systematic Review en
dc.type Review Article
dc.contributor.organization Department of Oral and Maxillofacial Diseases
dc.contributor.organization TRIMM - Translational Immunology Research Program
dc.contributor.organization University of Helsinki
dc.contributor.organization Clinicum
dc.contributor.organization Research Programs Unit
dc.contributor.organization Centre of Excellence in Complex Disease Genetics
dc.contributor.organization Statistical and population genetics
dc.contributor.organization Department of Mathematics and Statistics
dc.contributor.organization Institute for Molecular Medicine Finland
dc.contributor.organization Biostatistics Helsinki
dc.contributor.organization Department of Public Health
dc.contributor.organization Helsinki Institute of Life Science HiLIFE
dc.contributor.organization HUSLAB
dc.description.reviewstatus Peer reviewed
dc.relation.doi https://doi.org/10.1111/cas.14189
dc.relation.issn 1347-9032
dc.rights.accesslevel openAccess
dc.type.version publishedVersion

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