Antimicrobial and Anti-Inflammatory Lingonberry Mouthwash-A Clinical Pilot Study in the Oral Cavity

Show full item record



Permalink

http://hdl.handle.net/10138/306798

Citation

Parnanen , P , Nikula-Ijäs , P & Sorsa , T 2019 , ' Antimicrobial and Anti-Inflammatory Lingonberry Mouthwash-A Clinical Pilot Study in the Oral Cavity ' , Microorganisms , vol. 7 , no. 9 , 331 . https://doi.org/10.3390/microorganisms7090331

Title: Antimicrobial and Anti-Inflammatory Lingonberry Mouthwash-A Clinical Pilot Study in the Oral Cavity
Author: Parnanen, Pirjo; Nikula-Ijäs, Pirjo; Sorsa, Timo
Other contributor: University of Helsinki, HUS Head and Neck Center
University of Helsinki, Molecular and Integrative Biosciences Research Programme
University of Helsinki, HUS Head and Neck Center




Date: 2019-09
Language: eng
Number of pages: 10
Belongs to series: Microorganisms
ISSN: 2076-2607
DOI: https://doi.org/10.3390/microorganisms7090331
URI: http://hdl.handle.net/10138/306798
Abstract: Fermented lingonberry juice was designed to be used as a mouthwash. Our aim was to study the antimicrobial and anti-inflammatory effects of the mouthwash in the oral cavity. A clinical study of 30 adult participants was performed. A total of 20 participants used 10 mL of the mouthwash twice daily for two weeks and 10 participants used 20 mL twice daily for one week. Streptococcus mutans, Candida and Lactobacilli were cultivated at the beginning, after the mouthwash period and after a washout period. At the same timepoints an additional oral mouthrinse was collected for chair-side/point-of-care (POC)-PerioSafe (R)/OraLyzer (R) aMMP-8 quantitative on-line evaluation, and an oral clinical investigation was performed. Mean Streptococcus mutans and Candida counts, visible plaque index (VPI) and bleeding on probing (BOP) were reduced, and Lactobacilli counts increased during the lingonberry mouthwash period. The aMMP-8 mouthrinses showed reduced values in both test groups when compared to the startpoint. The mouthrinse aMMP-8 reduction correlated with the reductions in microbial counts, VPI and BOP. Based on the results, fermented lingonberry juice seems a promising aid in oral homecare, diminishing the microbial and related proinflammatory burden by balancing the oral microbial flora and gradually lowering the inflammatory load in the oral cavity.
Subject: Vaccinium vitis-idaea
fermentation
mouthwashes
Streptococcus mutans
Candida
Lactobacillus
point-of-care systems
anti-infective agents
dental plaque index
MATRIX METALLOPROTEINASES
PATHOGENESIS
313 Dentistry
Rights:


Files in this item

Total number of downloads: Loading...

Files Size Format View
microorganisms_07_00331_v2.pdf 2.415Mb PDF View/Open

This item appears in the following Collection(s)

Show full item record