Anatomy and function of the vertebral column lymphatic network in mice

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Jacob , L , Boisserand , L S B , Geraldo , L H M , Neto , J D B , Mathivet , T , Antila , S , Barka , B , Xu , Y , Thomas , J-M , Pestel , J , Aigrot , M-S , Song , E , Nurmi , H , Lee , S , Alitalo , K , Renier , N , Eichmann , A & Thomas , J-L 2019 , ' Anatomy and function of the vertebral column lymphatic network in mice ' , Nature Communications , vol. 10 , 4594 .

Title: Anatomy and function of the vertebral column lymphatic network in mice
Author: Jacob, Laurent; Boisserand, Ligia Simoes Braga; Geraldo, Luiz Henrique Medeiros; Neto, Jose de Brito; Mathivet, Thomas; Antila, Salli; Barka, Besma; Xu, Yunling; Thomas, Jean-Mickael; Pestel, Juliette; Aigrot, Marie-Stephane; Song, Eric; Nurmi, Harri; Lee, Seyoung; Alitalo, Kari; Renier, Nicolas; Eichmann, Anne; Thomas, Jean-Leon
Other contributor: University of Helsinki, CAN-PRO - Translational Cancer Medicine Program
University of Helsinki, Kari Alitalo / Principal Investigator
University of Helsinki, HUSLAB

Date: 2019-10-09
Language: eng
Number of pages: 16
Belongs to series: Nature Communications
ISSN: 2041-1723
Abstract: Cranial lymphatic vessels (LVs) are involved in the transport of fluids, macromolecules and central nervous system (CNS) immune responses. Little information about spinal LVs is available, because these delicate structures are embedded within vertebral tissues and difficult to visualize using traditional histology. Here we show an extended vertebral column LV network using three-dimensional imaging of decalcified iDISCO(+)-clarified spine segments. Vertebral LVs connect to peripheral sensory and sympathetic ganglia and form metameric vertebral circuits connecting to lymph nodes and the thoracic duct. They drain the epidural space and the dura mater around the spinal cord and associate with leukocytes. Vertebral LVs remodel extensively after spinal cord injury and VEGF-C-induced vertebral lymphangiogenesis exacerbates the inflammatory responses, T cell infiltration and demyelination following focal spinal cord lesion. Therefore, vertebral LVs add to skull meningeal LVs as gatekeepers of CNS immunity and may be potential targets to improve the maintenance and repair of spinal tissues.
3111 Biomedicine

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