DNA Methylation Trajectories During Pregnancy

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dc.contributor.author Gruzieva, Olena
dc.contributor.author Merid, Simon Kebede
dc.contributor.author Chen, Su
dc.contributor.author Mukherjee, Nandini
dc.contributor.author Hedman, Anna M.
dc.contributor.author Almqvist, Catarina
dc.contributor.author Andolf, Ellika
dc.contributor.author Jiang, Yu
dc.contributor.author Kere, Juha
dc.contributor.author Scheynius, Annika
dc.contributor.author Soderhall, Cilia
dc.contributor.author Ullemar, Vilhelmina
dc.contributor.author Karmaus, Wilfried
dc.contributor.author Melen, Erik
dc.contributor.author Arshad, Syed Hasan
dc.contributor.author Pershagen, Goran
dc.date.accessioned 2019-11-07T14:33:01Z
dc.date.available 2019-11-07T14:33:01Z
dc.date.issued 2019-08
dc.identifier.citation Gruzieva , O , Merid , S K , Chen , S , Mukherjee , N , Hedman , A M , Almqvist , C , Andolf , E , Jiang , Y , Kere , J , Scheynius , A , Soderhall , C , Ullemar , V , Karmaus , W , Melen , E , Arshad , S H & Pershagen , G 2019 , ' DNA Methylation Trajectories During Pregnancy ' , Epigenetics insights , vol. 12 , 2516865719867090 . https://doi.org/10.1177/2516865719867090
dc.identifier.other PURE: 127971396
dc.identifier.other PURE UUID: 09d38953-7ef0-4e4b-aba4-8ca8d31be885
dc.identifier.other WOS: 000489623700001
dc.identifier.uri http://hdl.handle.net/10138/306817
dc.description.abstract There is emerging evidence on DNA methylation (DNAm) variability over time; however, little is known about dynamics of DNAm patterns during pregnancy. We performed an epigenome-wide longitudinal DNAm study of a well-characterized sample of young women from the Swedish Born into Life study, with repeated blood sampling before, during and after pregnancy (n = 21), using the Illumina Infinium MethylationEPIC array. We conducted a replication in the Isle of Wight third-generation birth cohort (n = 27), using the Infinium HumanMethylation450k BeadChip. We identified 196 CpG sites displaying intra-individual longitudinal change in DNAm with a false discovery rate (FDR) P <.05. Most of these (91%) showed a decrease in average methylation levels over the studied period. We observed several genes represented by > 3 differentially methylated CpGs: HOXB3, AVP, LOC100996291, and MicroRNA 10a. Of 36 CpGs available in the replication cohort, 17 were replicated, all but 2 with the same direction of association (replication P <.05). Biological pathway analysis demonstrated that FDR-significant CpGs belong to genes overrepresented in metabolism-related pathways, such as adipose tissue development, regulation of insulin receptor signaling, and mammary gland fat development. These results contribute to a better understanding of the biological mechanisms underlying important physiological alterations and adaptations for pregnancy and lactation. en
dc.format.extent 9
dc.language.iso eng
dc.relation.ispartof Epigenetics insights
dc.rights cc_by_nc
dc.rights.uri info:eu-repo/semantics/openAccess
dc.subject Cohort
dc.subject DNA methylation
dc.subject Illumina EPIC and Infinium chip
dc.subject pregnancy
dc.subject GENE-EXPRESSION
dc.subject LUNG
dc.subject PACKAGE
dc.subject AGE
dc.subject 3111 Biomedicine
dc.subject 1184 Genetics, developmental biology, physiology
dc.title DNA Methylation Trajectories During Pregnancy en
dc.type Article
dc.contributor.organization STEMM - Stem Cells and Metabolism Research Program
dc.contributor.organization Juha Kere / Principal Investigator
dc.contributor.organization Research Programs Unit
dc.contributor.organization University Management
dc.contributor.organization University of Helsinki
dc.description.reviewstatus Peer reviewed
dc.relation.doi https://doi.org/10.1177/2516865719867090
dc.relation.issn 2516-8657
dc.rights.accesslevel openAccess
dc.type.version publishedVersion

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