Repeatedly recurring pleomorphic adenoma : a therapeutic challenge

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dc.contributor University of Helsinki, Korva-, nenä- ja kurkkutautien klinikka en
dc.contributor University of Helsinki, Department of Pathology en
dc.contributor University of Helsinki, HUS Head and Neck Center en
dc.contributor University of Helsinki, Department of Ophthalmology and Otorhinolaryngology en Aro, K. Valle, J. Tarkkanen, J. Mäkitie, A. Atula, T. 2019-11-08T06:19:01Z 2019-11-08T06:19:01Z 2019-06
dc.identifier.citation Aro , K , Valle , J , Tarkkanen , J , Mäkitie , A & Atula , T 2019 , ' Repeatedly recurring pleomorphic adenoma : a therapeutic challenge ' , Acta otorhinolaryngologica italica , vol. 39 , no. 3 , pp. 156-161 . en
dc.identifier.issn 0392-100X
dc.identifier.other PURE: 127982587
dc.identifier.other PURE UUID: 39fe519d-e030-454a-81e9-7385a171cb4e
dc.identifier.other WOS: 000489654300004
dc.identifier.other ORCID: /0000-0002-6560-1128/work/64323865
dc.description.abstract Pleomorphic adenoma (PA) is the most common tumour of the salivary glands, and can recur even after proper surgery. The extent and timing of surgery for recurrent tumours remains controversial, and multiple recurrences pose a special challenge. We evaluated all recurrent PAs (RPAs) treated at the Helsinki University Hospital through 2004-2013 focusing on patients with multiple recurrences. Follow-up data were obtained until January 2018. Of the 47 patients, 70% were women and the median age was 33.5 years. Most of the RPAs were located in the parotid gland (87%), and six (13%) in the submandibular gland. One-third (17/47) of tumours had been primarily excised. This patient population experienced 75 recurrent events in total with two or more recurrences in 14 patients (30%). The time interval between recurrences shortened after each recurrent event and the tumour was more likely to be multifocal. At the end of the follow-up period, 15% had recurrent disease and malignant transformation had occurred in 6%. Treatment for PA and RPA is challenging and requires centralised management. Patients with RPA are often young and recurrences may cause lifelong morbidity, especially when the tumour recurs repeatedly. The utilisation and timing of postoperative radiotherapy needs to be discussed as well as the potential risk for malignant transformation in this patient population. en
dc.format.extent 6
dc.language.iso eng
dc.relation.ispartof Acta otorhinolaryngologica italica
dc.rights en
dc.subject Salivary gland en
dc.subject Pleomorphic adenoma en
dc.subject Adenoma en
dc.subject Treatment en
dc.subject Outcome en
dc.subject PAROTID-GLAND en
dc.subject RISK-FACTORS en
dc.subject RECURRENCE en
dc.subject SURGERY en
dc.subject TUMORS en
dc.subject RADIOTHERAPY en
dc.subject EXPERIENCE en
dc.subject MANAGEMENT en
dc.subject 3125 Otorhinolaryngology, ophthalmology en
dc.title Repeatedly recurring pleomorphic adenoma : a therapeutic challenge en
dc.type Article
dc.description.version Peer reviewed
dc.type.uri info:eu-repo/semantics/other
dc.type.uri info:eu-repo/semantics/publishedVersion

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