Microbe-host interplay in atopic dermatitis and psoriasis

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Fyhrquist , N , Muirhead , G , Prast-Nielsen , S , Jeanmougin , M , Olah , P , Skoog , T , Jules-Clement , G , Feld , M , Barrientos-Somarribas , M , Sinkko , H , van den Bogaard , E H , Zeeuwen , P L J M , Rikken , G , Schalkwijk , J , Niehues , H , Däubener , W , Eller , S K , Alexander , H , Pennino , D , Suomela , S , Tessas , I , Lybeck , E , Baran , A M , Darban , H , Gangwar , R S , Gerstel , U , Jahn , K , Karisola , P , Yan , L , Hansmann , B , Katayama , S , Meller , S , Bylesjo , M , Hupe , P , Levi-Schaffer , F , Greco , D , Ranki , A , Schröder , J M , Barker , J , Kere , J , Tsoka , S , Lauerma , A , Soumelis , V , Nestle , F O , Homey , B , Andersson , B & Alenius , H 2019 , ' Microbe-host interplay in atopic dermatitis and psoriasis ' , Nature Communications , vol. 10 , 4703 . https://doi.org/10.1038/s41467-019-12253-y

Title: Microbe-host interplay in atopic dermatitis and psoriasis
Author: Fyhrquist, Nanna; Muirhead, Gareth; Prast-Nielsen, Stefanie; Jeanmougin, Marine; Olah, Peter; Skoog, Tiina; Jules-Clement, Gerome; Feld, Micha; Barrientos-Somarribas, Mauricio; Sinkko, Hanna; van den Bogaard, Ellen H.; Zeeuwen, Patrick L. J. M.; Rikken, Gijs; Schalkwijk, Joost; Niehues, Hanna; Däubener, Walter; Eller, Silvia Kathrin; Alexander, Helen; Pennino, Davide; Suomela, Sari; Tessas, Ioannis; Lybeck, Emilia; Baran, Anna M.; Darban, Hamid; Gangwar, Roopesh Singh; Gerstel, Ulrich; Jahn, Katharina; Karisola, Piia; Yan, Lee; Hansmann, Britta; Katayama, Shintaro; Meller, Stephan; Bylesjo, Max; Hupe, Philippe; Levi-Schaffer, Francesca; Greco, Dario; Ranki, Annamari; Schröder, Jens M.; Barker, Jonathan; Kere, Juha; Tsoka, Sophia; Lauerma, Antti; Soumelis, Vassili; Nestle, Frank O.; Homey, Bernhard; Andersson, Björn; Alenius, Harri
Contributor organization: HUMI - Human Microbiome Research
Staff Services
Department of Bacteriology and Immunology
University of Helsinki
Department of Dermatology, Allergology and Venereology
HUS Inflammation Center
Institute of Biotechnology
University Management
Date: 2019-10-16
Language: eng
Number of pages: 15
Belongs to series: Nature Communications
ISSN: 2041-1723
DOI: https://doi.org/10.1038/s41467-019-12253-y
URI: http://hdl.handle.net/10138/306834
Abstract: Despite recent advances in understanding microbial diversity in skin homeostasis, the relevance of microbial dysbiosis in inflammatory disease is poorly understood. Here we perform a comparative analysis of skin microbial communities coupled to global patterns of cutaneous gene expression in patients with atopic dermatitis or psoriasis. The skin microbiota is analysed by 16S amplicon or whole genome sequencing and the skin transcriptome by microarrays, followed by integration of the data layers. We find that atopic dermatitis and psoriasis can be classified by distinct microbes, which differ from healthy volunteers microbiome composition. Atopic dermatitis is dominated by a single microbe (Staphylococcus aureus), and associated with a disease relevant host transcriptomic signature enriched for skin barrier function, tryptophan metabolism and immune activation. In contrast, psoriasis is characterized by co-occurring communities of microbes with weak associations with disease related gene expression. Our work provides a basis for biomarker discovery and targeted therapies in skin dysbiosis.
3121 General medicine, internal medicine and other clinical medicine
Peer reviewed: Yes
Rights: cc_by
Usage restriction: openAccess
Self-archived version: publishedVersion

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