Microbe-host interplay in atopic dermatitis and psoriasis

Show simple item record

dc.contributor University of Helsinki, HUMI - Human Microbiome Research en
dc.contributor University of Helsinki, Department of Bacteriology and Immunology en
dc.contributor University of Helsinki, Department of Dermatology, Allergology and Venereology en
dc.contributor University of Helsinki, Clinicum en
dc.contributor University of Helsinki, Department of Dermatology, Allergology and Venereology en
dc.contributor University of Helsinki, HUMI - Human Microbiome Research en
dc.contributor University of Helsinki, Institute of Biotechnology en
dc.contributor University of Helsinki, HUS Inflammation Center en
dc.contributor University of Helsinki, Kings College London en
dc.contributor University of Helsinki, HUS Inflammation Center en
dc.contributor University of Helsinki, HUMI - Human Microbiome Research en
dc.contributor.author Fyhrquist, Nanna
dc.contributor.author Muirhead, Gareth
dc.contributor.author Prast-Nielsen, Stefanie
dc.contributor.author Jeanmougin, Marine
dc.contributor.author Olah, Peter
dc.contributor.author Skoog, Tiina
dc.contributor.author Jules-Clement, Gerome
dc.contributor.author Feld, Micha
dc.contributor.author Barrientos-Somarribas, Mauricio
dc.contributor.author Sinkko, Hanna
dc.contributor.author van den Bogaard, Ellen H.
dc.contributor.author Zeeuwen, Patrick L. J. M.
dc.contributor.author Rikken, Gijs
dc.contributor.author Schalkwijk, Joost
dc.contributor.author Niehues, Hanna
dc.contributor.author Däubener, Walter
dc.contributor.author Eller, Silvia Kathrin
dc.contributor.author Alexander, Helen
dc.contributor.author Pennino, Davide
dc.contributor.author Suomela, Sari
dc.contributor.author Tessas, Ioannis
dc.contributor.author Lybeck, Emilia
dc.contributor.author Baran, Anna M.
dc.contributor.author Darban, Hamid
dc.contributor.author Gangwar, Roopesh Singh
dc.contributor.author Gerstel, Ulrich
dc.contributor.author Jahn, Katharina
dc.contributor.author Karisola, Piia
dc.contributor.author Yan, Lee
dc.contributor.author Hansmann, Britta
dc.contributor.author Katayama, Shintaro
dc.contributor.author Meller, Stephan
dc.contributor.author Bylesjo, Max
dc.contributor.author Hupe, Philippe
dc.contributor.author Levi-Schaffer, Francesca
dc.contributor.author Greco, Dario
dc.contributor.author Ranki, Annamari
dc.contributor.author Schröder, Jens M.
dc.contributor.author Barker, Jonathan
dc.contributor.author Kere, Juha
dc.contributor.author Tsoka, Sophia
dc.contributor.author Lauerma, Antti
dc.contributor.author Soumelis, Vassili
dc.contributor.author Nestle, Frank O.
dc.contributor.author Homey, Bernhard
dc.contributor.author Andersson, Björn
dc.contributor.author Alenius, Harri
dc.date.accessioned 2019-11-08T12:06:02Z
dc.date.available 2019-11-08T12:06:02Z
dc.date.issued 2019-10-16
dc.identifier.citation Fyhrquist , N , Muirhead , G , Prast-Nielsen , S , Jeanmougin , M , Olah , P , Skoog , T , Jules-Clement , G , Feld , M , Barrientos-Somarribas , M , Sinkko , H , van den Bogaard , E H , Zeeuwen , P L J M , Rikken , G , Schalkwijk , J , Niehues , H , Däubener , W , Eller , S K , Alexander , H , Pennino , D , Suomela , S , Tessas , I , Lybeck , E , Baran , A M , Darban , H , Gangwar , R S , Gerstel , U , Jahn , K , Karisola , P , Yan , L , Hansmann , B , Katayama , S , Meller , S , Bylesjo , M , Hupe , P , Levi-Schaffer , F , Greco , D , Ranki , A , Schröder , J M , Barker , J , Kere , J , Tsoka , S , Lauerma , A , Soumelis , V , Nestle , F O , Homey , B , Andersson , B & Alenius , H 2019 , ' Microbe-host interplay in atopic dermatitis and psoriasis ' , Nature Communications , vol. 10 , 4703 . https://doi.org/10.1038/s41467-019-12253-y en
dc.identifier.issn 2041-1723
dc.identifier.other PURE: 127993514
dc.identifier.other PURE UUID: 178d8467-0fd7-4ff6-a638-d6e1435bbd8f
dc.identifier.other WOS: 000490417700015
dc.identifier.other ORCID: /0000-0001-9195-9003/work/64323791
dc.identifier.other ORCID: /0000-0003-0635-2704/work/64325852
dc.identifier.uri http://hdl.handle.net/10138/306834
dc.description.abstract Despite recent advances in understanding microbial diversity in skin homeostasis, the relevance of microbial dysbiosis in inflammatory disease is poorly understood. Here we perform a comparative analysis of skin microbial communities coupled to global patterns of cutaneous gene expression in patients with atopic dermatitis or psoriasis. The skin microbiota is analysed by 16S amplicon or whole genome sequencing and the skin transcriptome by microarrays, followed by integration of the data layers. We find that atopic dermatitis and psoriasis can be classified by distinct microbes, which differ from healthy volunteers microbiome composition. Atopic dermatitis is dominated by a single microbe (Staphylococcus aureus), and associated with a disease relevant host transcriptomic signature enriched for skin barrier function, tryptophan metabolism and immune activation. In contrast, psoriasis is characterized by co-occurring communities of microbes with weak associations with disease related gene expression. Our work provides a basis for biomarker discovery and targeted therapies in skin dysbiosis. en
dc.format.extent 15
dc.language.iso eng
dc.relation.ispartof Nature Communications
dc.rights en
dc.subject STAPHYLOCOCCUS-AUREUS en
dc.subject HUMAN SKIN en
dc.subject INDOLEAMINE 2,3-DIOXYGENASE en
dc.subject DISEASE en
dc.subject IMMUNE en
dc.subject MECHANISMS en
dc.subject KERATINOCYTES en
dc.subject COLONIZATION en
dc.subject RECEPTOR en
dc.subject TISSUE en
dc.subject 3121 Internal medicine en
dc.title Microbe-host interplay in atopic dermatitis and psoriasis en
dc.type Article
dc.description.version Peer reviewed
dc.identifier.doi https://doi.org/10.1038/s41467-019-12253-y
dc.type.uri info:eu-repo/semantics/other
dc.type.uri info:eu-repo/semantics/publishedVersion
dc.contributor.pbl
dc.contributor.pbl
dc.contributor.pbl
dc.contributor.pbl
dc.contributor.pbl
dc.contributor.pbl
dc.contributor.pbl
dc.contributor.pbl
dc.contributor.pbl
dc.contributor.pbl

Files in this item

Total number of downloads: Loading...

Files Size Format View
s41467_019_12253_y.pdf 2.565Mb PDF View/Open

This item appears in the following Collection(s)

Show simple item record