Role of inflammation markers in the prediction of weight gain and development of obesity in adults – a prospective study

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Tuomisto , K , Jousilahti , P , Havulinna , A S , Borodulin , K , Männistö , S & Salomaa , V 2019 , ' Role of inflammation markers in the prediction of weight gain and development of obesity in adults – a prospective study ' , Metabolism open , vol. 3 , 100016 . https://doi.org/10.1016/j.metop.2019.100016

Title: Role of inflammation markers in the prediction of weight gain and development of obesity in adults – a prospective study
Author: Tuomisto, K.; Jousilahti, P.; Havulinna, A.S.; Borodulin, K.; Männistö, S.; Salomaa, V.
Contributor: University of Helsinki, Department of Public Health
University of Helsinki, Staff Services
Date: 2019-08-27
Language: eng
Number of pages: 6
Belongs to series: Metabolism open
ISSN: 2589-9368
URI: http://hdl.handle.net/10138/306860
Abstract: BACKGROUND AND AIMS There is a growing body of literature confirming the association between inflammation and obesity. Recent research suggests that inflammation may play a role in weight gain. The aim of the study was to analyse whether serum inflammatory markers predict weight gain or development of obesity in a prospective study design. METHODS AND RESULTS The baseline study (DILGOM 2007) consists of a population-based sample of 5024 Finnish men and women aged 25-75 years, of whom 3735 participated in the follow-up study in 2014. Baseline data collection included a questionnaire on health behaviour, physical examinations and blood samples including serum high-sensitivity C-Reactive Protein (hs-CRP), Interleukin-1 receptor antagonist (IL-1Ra), Interleukin-6 (IL-6), Tumor Necrosis Factor Alpha (TNF-alpha) and high molecular weight adiponectin (HMW adiponectin). Indicators of obesity were weight, body mass index (BMI), waist circumference and body fat percentage (% body fat). At baseline hs-CRP, IL-1Ra, IL-6, TNF-alpha and HMW adiponectin associated strongly (p
Subject: Inflammation
Obesity
Weight gain
Epidemiology
3111 Biomedicine
3121 General medicine, internal medicine and other clinical medicine
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