Chondroblastoma of bone in extremities. - A single centre study of 177 cases

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Laitinen , M K , Stevenson , J D , Evans , S , Abudu , A , Sumathi , V , Jeys , L M & Parry , M C 2019 , ' Chondroblastoma of bone in extremities. - A single centre study of 177 cases ' , Journal of bone oncology , vol. 17 , 100248 . https://doi.org/10.1016/j.jbo.2019.100248

Title: Chondroblastoma of bone in extremities. - A single centre study of 177 cases
Author: Laitinen, M. K.; Stevenson, J. D.; Evans, S.; Abudu, A.; Sumathi, V.; Jeys, L. M.; Parry, M. C.
Contributor: University of Helsinki, Clinicum
Date: 2019-08
Language: eng
Number of pages: 6
Belongs to series: Journal of bone oncology
ISSN: 2212-1366
URI: http://hdl.handle.net/10138/306862
Abstract: Introduction Chondroblastoma is a rare benign bone tumour that usually occurs in children and young adults. They are cartilaginous tumours arising in the epiphysis or apophysis of a long bone. The tumour is classified as benign, although rare cases of pulmonary metastases have been reported. The aims of this study were to describe clinical, radiographic characteristics of chondroblastoma; to analyse the local recurrence rate and complications associated with surgery. Material and methods This retrospective study included 177 patients, who had been diagnosed with a chondroblastoma in extremity between 1990 and 2015. Results The most common site was proximal tibia 20%, followed by proximal humerus 19%, proximal femur 18%, distal femur 16% and foot 15%. One patient has died of the disease and one patient is alive after being operated for lung metastases. There was local recurrence in 25/177 (14%) patients. The median time to local recurrence was 10 months (range 3-158 months). The most common site for local recurrence was proximal tibia (22.2%). The proximal femur was the location in 32/178 (18%) of the cases. 18/32 (56%) were in the greater trochanter and 14/32 (44%) in the femoral head. The mean age was lower in tumours located in femoral head when compared to the greater trochanter; 19.5 years and 13.9 years respectively (p=0.004). Tumours located in greater trochanter were all curetted without further complications. Local recurrence was seen more often in femoral head tumours, though without statistical significance; 3/14 (21%) and none, respectively (p=0.073). Conclusions Chondroblastoma is a rare benign to intermediate grade bone tumour with a potential to metastasise. Femoral head chondroblastoma is rare, presenting 4.5% of all chondroblastoma cases. Around 50% of the chondroblastoma in femoral head. occur in patients with open growth plates.
Subject: Chondroblastoma
Bone neoplasm
Femur head
Growth plate
RADIOFREQUENCY ABLATION
BONE
METASTASIS
3122 Cancers
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