GWAS on longitudinal growth traits reveals different genetic factors influencing infant, child, and adult BMI

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http://hdl.handle.net/10138/306871

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BIOS Consortium , Early Growth Genetics EGG Conso , Alves , A C , De Silva , N M G , Cousminer , D L , Eriksson , J G & Widen , E 2019 , ' GWAS on longitudinal growth traits reveals different genetic factors influencing infant, child, and adult BMI ' , Science Advances , vol. 5 , no. 9 , 3095 . https://doi.org/10.1126/sciadv.aaw3095

Titel: GWAS on longitudinal growth traits reveals different genetic factors influencing infant, child, and adult BMI
Författare: BIOS Consortium; Early Growth Genetics EGG Conso; Alves, Alexessander Couto; De Silva, N. Maneka G.; Cousminer, Diana L.; Eriksson, Johan G.; Widen, Elisabeth
Upphovmannens organisation: Institute for Molecular Medicine Finland
Research Programs Unit
Diabetes and Obesity Research Program
Johan Eriksson / Principal Investigator
Department of General Practice and Primary Health Care
HUS Helsinki and Uusimaa Hospital District
Centre of Excellence in Complex Disease Genetics
Elisabeth Ingrid Maria Widen / Principal Investigator
University Management
Genomic Discoveries and Clinical Translation
Datum: 2019-09
Språk: eng
Sidantal: 17
Tillhör serie: Science Advances
ISSN: 2375-2548
DOI: https://doi.org/10.1126/sciadv.aaw3095
Permanenta länken (URI): http://hdl.handle.net/10138/306871
Abstrakt: Early childhood growth patterns are associated with adult health, yet the genetic factors and the developmental stages involved are not fully understood. Here, we combine genome-wide association studies with modeling of longitudinal growth traits to study the genetics of infant and child growth, followed by functional, pathway, genetic correlation, risk score, and colocalization analyses to determine how developmental timings, molecular pathways, and genetic determinants of these traits overlap with those of adult health. We found a robust overlap between the genetics of child and adult body mass index (BMI), with variants associated with adult BMI acting as early as 4 to 6 years old. However, we demonstrated a completely distinct genetic makeup for peak BMI during infancy, influenced by variation at the LEPR/LEPROT locus. These findings suggest that different genetic factors control infant and child BMI. In light of the obesity epidemic, these findings are important to inform the timing and targets of prevention strategies.
Subject: BODY-MASS INDEX
GENOME-WIDE ASSOCIATION
BLOOD-PRESSURE
EARLY-LIFE
METABOLIC RISK
BIRTH COHORT
FTO GENE
ADIPOSITY
OBESITY
AGE
3111 Biomedicine
1184 Genetics, developmental biology, physiology
Referentgranskad: Ja
Användningsbegränsning: openAccess
Parallelpublicerad version: publishedVersion


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