GWAS on longitudinal growth traits reveals different genetic factors influencing infant, child, and adult BMI

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dc.contributor.author BIOS Consortium
dc.contributor.author Early Growth Genetics EGG Conso
dc.contributor.author Alves, Alexessander Couto
dc.contributor.author De Silva, N. Maneka G.
dc.contributor.author Cousminer, Diana L.
dc.contributor.author Eriksson, Johan G.
dc.contributor.author Widen, Elisabeth
dc.date.accessioned 2019-11-11T11:54:02Z
dc.date.available 2019-11-11T11:54:02Z
dc.date.issued 2019-09
dc.identifier.citation BIOS Consortium , Early Growth Genetics EGG Conso , Alves , A C , De Silva , N M G , Cousminer , D L , Eriksson , J G & Widen , E 2019 , ' GWAS on longitudinal growth traits reveals different genetic factors influencing infant, child, and adult BMI ' , Science Advances , vol. 5 , no. 9 , 3095 . https://doi.org/10.1126/sciadv.aaw3095
dc.identifier.other PURE: 128048438
dc.identifier.other PURE UUID: d0296f79-4a4a-4aa8-a2f6-6c72b22cbc0e
dc.identifier.other WOS: 000491128800014
dc.identifier.uri http://hdl.handle.net/10138/306871
dc.description.abstract Early childhood growth patterns are associated with adult health, yet the genetic factors and the developmental stages involved are not fully understood. Here, we combine genome-wide association studies with modeling of longitudinal growth traits to study the genetics of infant and child growth, followed by functional, pathway, genetic correlation, risk score, and colocalization analyses to determine how developmental timings, molecular pathways, and genetic determinants of these traits overlap with those of adult health. We found a robust overlap between the genetics of child and adult body mass index (BMI), with variants associated with adult BMI acting as early as 4 to 6 years old. However, we demonstrated a completely distinct genetic makeup for peak BMI during infancy, influenced by variation at the LEPR/LEPROT locus. These findings suggest that different genetic factors control infant and child BMI. In light of the obesity epidemic, these findings are important to inform the timing and targets of prevention strategies. en
dc.format.extent 17
dc.language.iso eng
dc.relation.ispartof Science Advances
dc.rights.uri info:eu-repo/semantics/openAccess
dc.subject BODY-MASS INDEX
dc.subject GENOME-WIDE ASSOCIATION
dc.subject BLOOD-PRESSURE
dc.subject EARLY-LIFE
dc.subject METABOLIC RISK
dc.subject BIRTH COHORT
dc.subject FTO GENE
dc.subject ADIPOSITY
dc.subject OBESITY
dc.subject AGE
dc.subject 3111 Biomedicine
dc.subject 1184 Genetics, developmental biology, physiology
dc.title GWAS on longitudinal growth traits reveals different genetic factors influencing infant, child, and adult BMI en
dc.type Article
dc.contributor.organization Institute for Molecular Medicine Finland
dc.contributor.organization Research Programs Unit
dc.contributor.organization Diabetes and Obesity Research Program
dc.contributor.organization Johan Eriksson / Principal Investigator
dc.contributor.organization Department of General Practice and Primary Health Care
dc.contributor.organization HUS Helsinki and Uusimaa Hospital District
dc.contributor.organization Centre of Excellence in Complex Disease Genetics
dc.contributor.organization Elisabeth Ingrid Maria Widen / Principal Investigator
dc.contributor.organization University Management
dc.contributor.organization Genomic Discoveries and Clinical Translation
dc.description.reviewstatus Peer reviewed
dc.relation.doi https://doi.org/10.1126/sciadv.aaw3095
dc.relation.issn 2375-2548
dc.rights.accesslevel openAccess
dc.type.version publishedVersion

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