Extracellular interleukin-17F has a protective effect in oral tongue squamous cell carcinoma

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http://hdl.handle.net/10138/306897

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Almahmoudi , R , Salem , A , Sievilaeinen , M , Sundquist , E , Almangush , A , Toppila-Salmi , S , Paavonen , T , Salo , T & Al-Samadi , A 2018 , ' Extracellular interleukin-17F has a protective effect in oral tongue squamous cell carcinoma ' , Head & Neck , vol. 40 , no. 10 , pp. 2155-2165 . https://doi.org/10.1002/hed.25207

Title: Extracellular interleukin-17F has a protective effect in oral tongue squamous cell carcinoma
Author: Almahmoudi, Rabeia; Salem, Abdelhakim; Sievilaeinen, Meri; Sundquist, Elias; Almangush, Alhadi; Toppila-Salmi, Sanna; Paavonen, Timo; Salo, Tuula; Al-Samadi, Ahmed
Contributor: University of Helsinki, Department of Oral and Maxillofacial Diseases
University of Helsinki, Invärtes medicin enhet
University of Helsinki, Department of Oral and Maxillofacial Diseases
University of Helsinki, Oral and Maxillofacial Surgery
University of Helsinki, Sanna Katriina Toppila-Salmi / Principal Investigator
University of Helsinki, Clinicum
University of Helsinki, Clinicum
Date: 2018-10
Language: eng
Number of pages: 11
Belongs to series: Head & Neck
ISSN: 1043-3074
URI: http://hdl.handle.net/10138/306897
Abstract: Background Oral tongue squamous cell carcinoma (SCC) is characterized by early metastasis and poor prognosis. Interleukin-17F (IL-17F) plays a protective role in many tumors. However, IL-17F expression in oral tongue SCC tissue has not been investigated. MethodsResultsImmunostaining of 83 oral tongue SCC specimens and blinded-scoring were used to map IL-17F expression, location, and distribution. Survival curves were constructed according to Kaplan-Meier method. The Cox proportional hazard model was applied for univariate and multivariate survival analyses. Mast cells are the major source of IL-17F in oral tongue SCC. In multivariate analysis, only the extracellular mast cell-derived IL-17F at the tumor invasion front was associated with better disease-specific survival in patients with all-stages and early-stages of oral tongue SCC. ConclusionExtracellular mast cell-derived IL-17F is antitumorigenic in oral tongue SCC. It separates patients with early-stage disease who are at high risk from patients who are at low risk. Furthermore, when analyzing tentative prognostic molecules, we conclude that in addition to the staining intensity, attention must be paid to the cellular source, distribution, and location of the molecule.
Subject: interleukin-17F
mast cells
prognosis
squamous cell carcinoma
tongue
CANCER
IL-17
INFILTRATION
INFLAMMATION
GROWTH
HEAD
3125 Otorhinolaryngology, ophthalmology
313 Dentistry
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