Early gestational ethanol exposure in mice : Effects on brain structure, energy metabolism and adiposity in adult offspring

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Zhang , C R , Kurniawan , N D , Yamada , L , Fleming , W , Kaminen-Ahola , N , Ahola , A , Galloway , G & Chong , S 2019 , ' Early gestational ethanol exposure in mice : Effects on brain structure, energy metabolism and adiposity in adult offspring ' , Alcohol (New York) , vol. 75 , pp. 1-10 . https://doi.org/10.1016/j.alcohol.2018.04.008

Title: Early gestational ethanol exposure in mice : Effects on brain structure, energy metabolism and adiposity in adult offspring
Author: Zhang, Christine R.; Kurniawan, Nyoman D.; Yamada, Lisa; Fleming, Whitney; Kaminen-Ahola, Nina; Ahola, Arttu; Galloway, Graham; Chong, Suyinn
Contributor organization: Department of Medical and Clinical Genetics
Medicum
University of Helsinki
Environmental Epigenetics Laboratory
Date: 2019-03
Language: eng
Number of pages: 10
Belongs to series: Alcohol (New York)
ISSN: 0741-8329
DOI: https://doi.org/10.1016/j.alcohol.2018.04.008
URI: http://hdl.handle.net/10138/306943
Abstract: We examined whether an early-life event ethanol exposure in the initial stages of pregnancy affected offspring brain structure, energy metabolism, and body composition in later life. Consumption of 10% (v/v) ethanol by inbred C57BL/6J female mice from 0.5 to 8.5 days post coitum was used to model alcohol exposure during the first 3-4 weeks of gestation in humans, when pregnancy is not typically recognized. At adolescence (postnatal day [P] 28) and adulthood (P64), the brains of male offspring were scanned ex vivo using ultra-high field (16.4 T) magnetic resonance imaging and diffusion tensor imaging. Energy metabolism and body composition were measured in adulthood by indirect calorimetry and dual energy X-ray absorptiometry (DXA), respectively. Ethanol exposure had no substantial impact on white matter organization in the anterior commissure, corpus callosum, hippocampal commissure, internal capsule, optic tract, or thalamus. Whole brain volume and the volumes of the neocortex, cerebellum, and caudate putamen were also unaffected. Subtle, but non-significant, effects were observed on the hippocampus and the hypothalamus in adult ethanol-exposed male offspring. Ethanol exposure was additionally associated with a trend toward decreased oxygen consumption, carbon dioxide production, and reduced daily energy expenditure, as well as significantly increased adiposity, albeit with normal body weight and food intake, in adult male offspring. In summary, ethanol exposure restricted to early gestation had subtle long-term effects on the structure of specific brain regions in male offspring. The sensitivity of the hippocampus to ethanol-induced damage is reminiscent of that reported by other studies despite differences in the level, timing, and duration of exposure and likely contributes to the cognitive impairment that characteristically results from prenatal ethanol exposure. The hypothalamus plays an important role in regulating metabolism and energy homeostasis. Our finding of altered daily energy expenditure and adiposity in adult ethanol-exposed males is consistent with the idea that central nervous system abnormalities also underpin some of the metabolic phenotypes associated with ethanol exposure in pregnancy. (C) 2018 Elsevier Inc. All rights reserved.
Subject: Prenatal
Alcohol
Brain structure
Energy metabolism
Body composition
PRENATAL ALCOHOL EXPOSURE
POSSIBLE MECHANISM
SPECTRUM DISORDER
GENE-EXPRESSION
ANIMAL-MODELS
ACUTE INSULT
MOUSE MODEL
OBESITY
CHILDREN
CONSUMPTION
3111 Biomedicine
317 Pharmacy
Peer reviewed: Yes
Rights: cc_by_nc_nd
Usage restriction: openAccess
Self-archived version: acceptedVersion


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