Global, regional, and national burden of stroke, 1990-2016 : a systematic analysis for the Global Burden of Disease Study 2016

Show full item record



GBD 2016 Stroke Collaborators , Johnson , C O , Minh Nguyen , Roth , G A , Kivimäki , M , Meretoja , A , Meretoja , T J & Weiderpass , E 2019 , ' Global, regional, and national burden of stroke, 1990-2016 : a systematic analysis for the Global Burden of Disease Study 2016 ' , Lancet Neurology , vol. 18 , no. 5 , pp. 439-458 .

Title: Global, regional, and national burden of stroke, 1990-2016 : a systematic analysis for the Global Burden of Disease Study 2016
Author: GBD 2016 Stroke Collaborators; Johnson, Catherine Owens; Minh Nguyen; Roth, Gregory A.; Kivimäki, Mika; Meretoja, Atte; Meretoja, Tuomo J.; Weiderpass, Elisabete
Contributor organization: Department of Public Health
University of Helsinki
HUS Neurocenter
Department of Neurosciences
Neurologian yksikkö
HUS Comprehensive Cancer Center
Staff Services
Department of Oncology
Department of Medical and Clinical Genetics
Date: 2019-05
Language: eng
Number of pages: 20
Belongs to series: Lancet Neurology
ISSN: 1474-4422
Abstract: Background Stroke is a leading cause of mortality and disability worldwide and the economic costs of treatment and post-stroke care are substantial. The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) provides a systematic, comparable method of quantifying health loss by disease, age, sex, year, and location to provide information to health systems and policy makers on more than 300 causes of disease and injury, including stroke. The results presented here are the estimates of burden due to overall stroke and ischaemic and haemorrhagic stroke from GBD 2016. Methods We report estimates and corresponding uncertainty intervals (UIs), from 1990 to 2016, for incidence, prevalence, deaths, years of life lost (YLLs), years lived with disability (YLDs), and disability-adjusted life-years (DALYs). DALYs were generated by summing YLLs and YLDs. Cause-specific mortality was estimated using an ensemble modelling process with vital registration and verbal autopsy data as inputs. Non-fatal estimates were generated using Bayesian meta-regression incorporating data from registries, scientific literature, administrative records, and surveys. The Socio-demographic Index (SDI), a summary indicator generated using educational attainment, lagged distributed income, and total fertility rate, was used to group countries into quintiles. Findings In 2016, there were 5.5 million (95% UI 5.3 to 5.7) deaths and 116.4 million (111.4 to 121.4) DALYs due to stroke. The global age-standardised mortality rate decreased by 36.2% (-39.3 to -33.6) from 1990 to 2016, with decreases in all SDI quintiles. Over the same period, the global age-standardised DALY rate declined by 34.2% (-37.2 to -31.5), also with decreases in all SDI quintiles. There were 13.7 million (12.7 to 14.7) new stroke cases in 2016. Global age-standardised incidence declined by 8.1% (-10.7 to -5.5) from 1990 to 2016 and decreased in all SDI quintiles except the middle SDI group. There were 80.1 million (74.1 to 86.3) prevalent cases of stroke globally in 2016; 41.1 million (38.0 to 44.3) in women and 39.0 million (36.1 to 42.1) in men. Interpretation Although age-standardised mortality rates have decreased sharply from 1990 to 2016, the decrease in age-standardised incidence has been less steep, indicating that the burden of stroke is likely to remain high. Planned updates to future GBD iterations include generating separate estimates for subarachnoid haemorrhage and intracerebral haemorrhage, generating estimates of transient ischaemic attack, and including atrial fibrillation as a risk factor. Copyright (C) 2019 The Author(s). Published by Elsevier Ltd.
3112 Neurosciences
3124 Neurology and psychiatry
Peer reviewed: Yes
Rights: cc_by
Usage restriction: openAccess
Self-archived version: publishedVersion

Files in this item

Total number of downloads: Loading...

Files Size Format View
Global_regional ... _of_Disease_Study_2016.pdf 1.340Mb PDF View/Open
1_s2.0_S1474442219300341_main.pdf 1.339Mb PDF View/Open

This item appears in the following Collection(s)

Show full item record