Optical techniques for breath analysis : from single to multi-species detection

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dc.contributor.author Metsälä, M.
dc.date.accessioned 2019-11-25T09:25:01Z
dc.date.available 2019-11-25T09:25:01Z
dc.date.issued 2018-04
dc.identifier.citation Metsälä , M 2018 , ' Optical techniques for breath analysis : from single to multi-species detection ' , Journal of Breath Research , vol. 12 , no. 2 , 027104 . https://doi.org/10.1088/1752-7163/aa8a31
dc.identifier.other PURE: 98090269
dc.identifier.other PURE UUID: b3387c50-30f0-44f7-a7e3-0203e7b8d344
dc.identifier.other WOS: 000422903900002
dc.identifier.other Scopus: 85040862384
dc.identifier.other ORCID: /0000-0002-0716-7132/work/44019083
dc.identifier.uri http://hdl.handle.net/10138/307287
dc.description.abstract Optical spectroscopy can be used for trace-level gas analysis in different applications, including exhaled breath research. A common approach is the targeted on-line, real-time analysis of small molecules (two to five atoms). Currently, the methodology is normally used for the detection of single analytes at trace levels, or two to three species at most at the same time. The main limitation preventing sensitive multi-species detection has been the limited fast scanning range of the lasers used as light sources. This limitation is currently being eliminated by the availability of optical frequency combs (OFC) which offer wide spectral bandwidths and the benefits of a laser-type light source. Recent advances in mid-infrared OFC technology allow measurements in the so-called molecular fingerprint region of the electromagnetic spectrum, where many molecules have strong fundamental vibrational transitions that enable sensitive detection. Several technical hurdles remain to be overcome, but if these problems can be solved laser absorption spectroscopy has the potential to challenge mass spectrometry in on-line multi-species trace gas analysis. en
dc.format.extent 6
dc.language.iso eng
dc.relation.ispartof Journal of Breath Research
dc.rights.uri info:eu-repo/semantics/openAccess
dc.subject breath analysis
dc.subject laser spectroscopy
dc.subject optical frequency comb
dc.subject optical spectroscopy
dc.subject FREQUENCY COMBS
dc.subject NITRIC-OXIDE
dc.subject SPECTROSCOPY
dc.subject 116 Chemical sciences
dc.subject 114 Physical sciences
dc.title Optical techniques for breath analysis : from single to multi-species detection en
dc.type Article
dc.contributor.organization Department of Chemistry
dc.description.reviewstatus Peer reviewed
dc.relation.doi https://doi.org/10.1088/1752-7163/aa8a31
dc.relation.issn 1752-7155
dc.rights.accesslevel openAccess
dc.type.version acceptedVersion

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