The Gut Microbiota in the First Decade of Life

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Derrien , M , Alvarez , A-S & de Vos , W M 2019 , ' The Gut Microbiota in the First Decade of Life ' , Trends in Microbiology , vol. 27 , no. 12 , pp. 997-1010 . https://doi.org/10.1016/j.tim.2019.08.001

Title: The Gut Microbiota in the First Decade of Life
Author: Derrien, Muriel; Alvarez, Anne-Sophie; de Vos, Willem M.
Contributor: University of Helsinki, Medicum
Date: 2019-12
Language: eng
Number of pages: 14
Belongs to series: Trends in Microbiology
ISSN: 0966-842X
URI: http://hdl.handle.net/10138/307545
Abstract: Appreciation of the importance of the gut microbiome is growing, and it is becoming increasingly relevant to identify preventive or therapeutic solutions targeting it. The composition and function of the gut microbiota are relatively well described for infants (less than 3 years) and adults, but have been largely overlooked in pre-school (3-6 years) and primary school-age (6-12 years) children, as well as teenagers (12-18 years). Early reports suggested that the infant microbiota would attain an adult-like structure at the age of 3 years, but recent studies have suggested that microbiota development may take longer. This development time is of key importance because there is evidence to suggest that deviations in this development may have consequences in later life. In this review, we provide an overview of current knowledge concerning the gut microbiota, its evolution, variation, and response to dietary challenges during the first decade of life with a focus on healthy pre-school and primary school-age children (up to 12 years) from various populations around the globe. This knowledge should facilitate the identification of diet-based approaches targeting individuals of this age group, to promote the development of a healthy microbiota in later life.
Subject: INTESTINAL MICROBIOTA
GALACTO-OLIGOSACCHARIDES
TEMPORAL DEVELOPMENT
IRON FORTIFICATION
CALCIUM-ABSORPTION
DIETARY FIBER
BODY SITES
CHILDREN
STABILITY
INFANTS
1182 Biochemistry, cell and molecular biology
1183 Plant biology, microbiology, virology
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