Common Nodes of Virus-Host Interaction Revealed Through an Integrated Network Analysis

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http://hdl.handle.net/10138/307587

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Bösl , K , Ianevski , A , Than , T T , Andersen , P I , Kuivanen , S , Teppor , M , Zusinaite , E , Dumpis , U , Vitkauskiene , A , Cox , R J , Kallio-Kokko , H , Bergqvist , A , Tenson , T , Merits , A , Oksenych , V , Bjørås , M , Anthonsen , M W , Shum , D , Kaarbø , M , Vapalahti , O , Windisch , M P , Superti-Furga , G , Snijder , B , Kainov , D & Kandasamy , R K 2019 , ' Common Nodes of Virus-Host Interaction Revealed Through an Integrated Network Analysis ' , Frontiers in Immunology , vol. 10 , 2186 . https://doi.org/10.3389/fimmu.2019.02186

Title: Common Nodes of Virus-Host Interaction Revealed Through an Integrated Network Analysis
Author: Bösl, Korbinian; Ianevski, Aleksandr; Than, Thoa T.; Andersen, Petter I.; Kuivanen, Suvi; Teppor, Mona; Zusinaite, Eva; Dumpis, Uga; Vitkauskiene, Astra; Cox, Rebecca J.; Kallio-Kokko, Hannimari; Bergqvist, Anders; Tenson, Tanel; Merits, Andres; Oksenych, Valentyn; Bjørås, Magnar; Anthonsen, Marit W.; Shum, David; Kaarbø, Mari; Vapalahti, Olli; Windisch, Marc P.; Superti-Furga, Giulio; Snijder, Berend; Kainov, Denis; Kandasamy, Richard K.
Contributor: University of Helsinki, Viral Zoonosis Research Unit
University of Helsinki, HUSLAB
University of Helsinki, Department of Virology
University of Helsinki, Norwegian University of Science and Technology (NTNU)
Date: 2019-10-04
Language: eng
Number of pages: 12
Belongs to series: Frontiers in Immunology
ISSN: 1664-3224
URI: http://hdl.handle.net/10138/307587
Abstract: Viruses are one of the major causes of acute and chronic infectious diseases and thus a major contributor to the global burden of disease. Several studies have shown how viruses have evolved to hijack basic cellular pathways and evade innate immune response by modulating key host factors and signaling pathways. A collective view of these multiple studies could advance our understanding of virus-host interactions and provide new therapeutic perspectives for the treatment of viral diseases. Here, we performed an integrative meta-analysis to elucidate the 17 different host-virus interactomes. Network and bioinformatics analyses showed how viruses with small genomes efficiently achieve the maximal effect by targeting multifunctional and highly connected host proteins with a high occurrence of disordered regions. We also identified the core cellular process subnetworks that are targeted by all the viruses. Integration with functional RNA interference (RNAi) datasets showed that a large proportion of the targets are required for viral replication. Furthermore, we performed an interactome-informed drug re-purposing screen and identified novel activities for broad-spectrum antiviral agents against hepatitis C virus and human metapneumovirus. Altogether, these orthogonal datasets could serve as a platform for hypothesis generation and follow-up studies to broaden our understanding of the viral evasion landscape.
Subject: virus-host interaction
protein-protein interaction
gene-drug interaction
innate immunity
viral evasion
network analysis
molecular innate immunity
DIRECTED THERAPIES
NEGATIVE REGULATOR
PROTEIN
MECHANISMS
GENOME
SALIPHENYLHALAMIDE
COMPLEXES
INFECTION
OBATOCLAX
EVASION
3111 Biomedicine
1183 Plant biology, microbiology, virology
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