Common Nodes of Virus-Host Interaction Revealed Through an Integrated Network Analysis

Show simple item record Bösl, Korbinian Ianevski, Aleksandr Than, Thoa T. Andersen, Petter I. Kuivanen, Suvi Teppor, Mona Zusinaite, Eva Dumpis, Uga Vitkauskiene, Astra Cox, Rebecca J. Kallio-Kokko, Hannimari Bergqvist, Anders Tenson, Tanel Merits, Andres Oksenych, Valentyn Bjørås, Magnar Anthonsen, Marit W. Shum, David Kaarbø, Mari Vapalahti, Olli Windisch, Marc P. Superti-Furga, Giulio Snijder, Berend Kainov, Denis Kandasamy, Richard K. 2019-11-28T10:33:02Z 2019-11-28T10:33:02Z 2019-10-04
dc.identifier.citation Bösl , K , Ianevski , A , Than , T T , Andersen , P I , Kuivanen , S , Teppor , M , Zusinaite , E , Dumpis , U , Vitkauskiene , A , Cox , R J , Kallio-Kokko , H , Bergqvist , A , Tenson , T , Merits , A , Oksenych , V , Bjørås , M , Anthonsen , M W , Shum , D , Kaarbø , M , Vapalahti , O , Windisch , M P , Superti-Furga , G , Snijder , B , Kainov , D & Kandasamy , R K 2019 , ' Common Nodes of Virus-Host Interaction Revealed Through an Integrated Network Analysis ' , Frontiers in Immunology , vol. 10 , 2186 .
dc.identifier.other PURE: 128449524
dc.identifier.other PURE UUID: 5a086a4d-24b4-4808-a04c-d3c9bd79136c
dc.identifier.other WOS: 000496975700001
dc.identifier.other ORCID: /0000-0003-2270-6824/work/65308329
dc.description.abstract Viruses are one of the major causes of acute and chronic infectious diseases and thus a major contributor to the global burden of disease. Several studies have shown how viruses have evolved to hijack basic cellular pathways and evade innate immune response by modulating key host factors and signaling pathways. A collective view of these multiple studies could advance our understanding of virus-host interactions and provide new therapeutic perspectives for the treatment of viral diseases. Here, we performed an integrative meta-analysis to elucidate the 17 different host-virus interactomes. Network and bioinformatics analyses showed how viruses with small genomes efficiently achieve the maximal effect by targeting multifunctional and highly connected host proteins with a high occurrence of disordered regions. We also identified the core cellular process subnetworks that are targeted by all the viruses. Integration with functional RNA interference (RNAi) datasets showed that a large proportion of the targets are required for viral replication. Furthermore, we performed an interactome-informed drug re-purposing screen and identified novel activities for broad-spectrum antiviral agents against hepatitis C virus and human metapneumovirus. Altogether, these orthogonal datasets could serve as a platform for hypothesis generation and follow-up studies to broaden our understanding of the viral evasion landscape. en
dc.format.extent 12
dc.language.iso eng
dc.relation.ispartof Frontiers in Immunology
dc.rights cc_by
dc.rights.uri info:eu-repo/semantics/openAccess
dc.subject virus-host interaction
dc.subject protein-protein interaction
dc.subject gene-drug interaction
dc.subject innate immunity
dc.subject viral evasion
dc.subject network analysis
dc.subject molecular innate immunity
dc.subject PROTEIN
dc.subject MECHANISMS
dc.subject GENOME
dc.subject COMPLEXES
dc.subject INFECTION
dc.subject OBATOCLAX
dc.subject EVASION
dc.subject 3111 Biomedicine
dc.subject 1183 Plant biology, microbiology, virology
dc.title Common Nodes of Virus-Host Interaction Revealed Through an Integrated Network Analysis en
dc.type Article
dc.contributor.organization Viral Zoonosis Research Unit
dc.contributor.organization Department of Virology
dc.contributor.organization University of Helsinki
dc.contributor.organization HUSLAB
dc.contributor.organization Medicum
dc.contributor.organization University Management
dc.contributor.organization Veterinary Biosciences
dc.contributor.organization Helsinki One Health (HOH)
dc.contributor.organization Olli Pekka Vapalahti / Principal Investigator
dc.contributor.organization Veterinary Microbiology and Epidemiology
dc.description.reviewstatus Peer reviewed
dc.relation.issn 1664-3224
dc.rights.accesslevel openAccess
dc.type.version publishedVersion

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