Synthesis of New Fused Heterocyclic 2-Quinolones and 3-Alkanonyl-4-Hydroxy-2-Quinolones

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Aly , A A , Hassan , A A , Mohamed , N K , Abd El-Haleem , L E , Bräse , S , Polamo , M , Nieger , M & Brown , A B 2019 , ' Synthesis of New Fused Heterocyclic 2-Quinolones and 3-Alkanonyl-4-Hydroxy-2-Quinolones ' , Molecules , vol. 24 , no. 20 . https://doi.org/10.3390/molecules24203782

Title: Synthesis of New Fused Heterocyclic 2-Quinolones and 3-Alkanonyl-4-Hydroxy-2-Quinolones
Author: Aly, Ashraf A.; Hassan, Alaa A.; Mohamed, Nasr K.; Abd El-Haleem, Lamiaa E.; Bräse, Stefan; Polamo, Mika; Nieger, Martin; Brown, Alan B.
Other contributor: University of Helsinki, Department of Chemistry
University of Helsinki, Department of Chemistry
Date: 2019-10
Language: eng
Number of pages: 13
Belongs to series: Molecules
ISSN: 1420-3049
DOI: https://doi.org/10.3390/molecules24203782
URI: http://hdl.handle.net/10138/307659
Abstract: Herein, we report the synthesis of 5,12-dihydropyrazino[2,3-c:5,6-c ' ]difuro[2,3-c:4,5-c ']-diquinoline-6,14(5H,12H)diones, 2-(4-hydroxy-2-oxo-1,2-dihydroquinolin-3-yl)-1,4-diphenyl- butane-1,4-diones and 4-(benzo-[d]oxazol-2-yl)-3-hydroxy-1H-[4,5]oxazolo[3,2-a]pyridine-1-one. The new candidates were synthesized and identified by different spectroscopic techniques, and X-ray crystallography.
Subject: 6
7-Disubstituted-4-hydroxy-quinoline-2-ones
2
3-dichloropyrazine
ANRORC process bis-pyrazinofuro-quinoline
1
4-diphenylbutane-1
4-diones
NMR
X-ray
FLUOROQUINOLONES
DERIVATIVES
INHIBITORS
MECHANISM
DESIGN
SIGNAL
116 Chemical sciences
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