Pectin and Mucin Enhance the Bioadhesion of Drug Loaded Nanofibrillated Cellulose Films

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Lauren , P , Paukkonen , H , Lipiainen , T , Dong , Y , Oksanen , T , Raikkonen , H , Ehlers , H , Laaksonen , P , Yliperttula , M & Laaksonen , T 2018 , ' Pectin and Mucin Enhance the Bioadhesion of Drug Loaded Nanofibrillated Cellulose Films ' , Pharmaceutical Research , vol. 35 , no. 7 , 145 . https://doi.org/10.1007/s11095-018-2428-z

Title: Pectin and Mucin Enhance the Bioadhesion of Drug Loaded Nanofibrillated Cellulose Films
Author: Lauren, Patrick; Paukkonen, Heli; Lipiainen, Tiina; Dong, Yujiao; Oksanen, Timo; Raikkonen, Heikki; Ehlers, Henrik; Laaksonen, Päivi; Yliperttula, Marjo; Laaksonen, Timo
Contributor: University of Helsinki, Faculty of Pharmacy
University of Helsinki, Faculty of Pharmacy
University of Helsinki, Faculty of Pharmacy
University of Helsinki, Faculty of Pharmacy
University of Helsinki, Faculty of Pharmacy
University of Helsinki, Doctoral Programme in Drug Research
University of Helsinki, Drug Research Program
University of Helsinki, Drug Research Program
Date: 2018-07
Language: eng
Number of pages: 14
Belongs to series: Pharmaceutical Research
ISSN: 0724-8741
URI: http://hdl.handle.net/10138/307694
Abstract: Purpose Bioadhesion is an important property of biological membranes, that can be utilized in pharmaceutical and biomedical applications. In this study, we have fabricated mucoadhesive drug releasing films with bio-based, non-toxic and biodegradable polymers that do not require chemical modifications. Methods Nanofibrillar cellulose and anionic type nanofibrillar cellulose were used as film forming materials with known mucoadhesive components mucin, pectin and chitosan as functional bioadhesion enhancers. Different polymer combinations were investigated to study the adhesiveness, solid state characteristics, film morphology, swelling, mechanical properties, drug release with the model compound metronidazole and in vitro cytotoxicity using TR146 cells to model buccal epithelium. Results SEM revealed lamellar structures within the films, which had a thickness ranging 40-240 mu m depending on the film polymer composition. All bioadhesive components were non-toxic and showed high adhesiveness. Rapid drug release was observed, as 60-80% of the total amount of metronidazole was released in 30 min depending on the film formulation. Conclusions The liquid molding used was a straightforward and simple method to produce drug releasing highly mucoadhesive films, which could be utilized in treating local oral diseases, such as periodontitis. All materials used were natural biodegradable polymers from renewable sources, which are generally regarded as safe.
Subject: bioadhesion
drug release
mucoadhesion
nanofibrillar cellulose
TR146
HUMAN BUCCAL EPITHELIUM
IN-VITRO
MUCOADHESIVE PROPERTIES
PERIODONTAL-DISEASE
DELIVERY SYSTEMS
NATIVE CELLULOSE
MATRIX TABLETS
RELEASE
CHITOSAN
IMPACT
317 Pharmacy
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