Entangled and colloidally stable microcrystalline cellulose matrices in controlled drug release

Show full item record



Permalink

http://hdl.handle.net/10138/307695

Citation

Dong , Y , Paukkonen , H , Fang , W , Kontturi , E , Laaksonen , T & Laaksonen , P 2018 , ' Entangled and colloidally stable microcrystalline cellulose matrices in controlled drug release ' , International Journal of Pharmaceutics , vol. 548 , no. 1 , pp. 113-119 . https://doi.org/10.1016/j.ijpharm.2018.06.022

Title: Entangled and colloidally stable microcrystalline cellulose matrices in controlled drug release
Author: Dong, Yujiao; Paukkonen, Heli; Fang, Wenwen; Kontturi, Eero; Laaksonen, Timo; Laaksonen, Paivi
Contributor: University of Helsinki, Faculty of Pharmacy
University of Helsinki, Drug Research Program
Date: 2018-09
Language: eng
Number of pages: 7
Belongs to series: International Journal of Pharmaceutics
ISSN: 0378-5173
URI: http://hdl.handle.net/10138/307695
Abstract: Drug release from a new type of matrix material consisting of partially fibrillated microcrystalline cellulose was investigated. A mechanical treatment of novel AaltoCell T cellulose microcrystals caused partial opening of the nanofibrillary structure of the cellulose particles and entanglement of individual particles led into formation of an elastic network of microcrystalline cellulose. The rheological properties of the stable hydrogel-like materials were characterised by shear rheometry. Model compounds metronidazole and lysozyme were successfully employed in drug release experiments carried out by delignified (bleached) and lignin-containing matrices. The viscosity as well as the lignin-content played a role in the release dynamics of the drugs. Microcrystalline AaltoCell T was proven as high-performing material for diffusion controlled release of the chosen model compounds and can be seen as a safe and economical alternative for novel matrix materials such as nanocellulose or cellulose derivatives.
Subject: Controlled release
Cellulose hydrogel
Microcrystalline cellulose
Diffusion-limited release
TEMPO-MEDIATED OXIDATION
WET-GRANULATION
LIGNIN
NANOCRYSTALS
EMULSIONS
LYSOZYME
PROTEINS
METRONIDAZOLE
HYDROLYSIS
EXCIPIENTS
317 Pharmacy
Rights:


Files in this item

Total number of downloads: Loading...

Files Size Format View
Drug_release_aaltocell_revised_final.docx 4.693Mb Microsoft Word View/Open

This item appears in the following Collection(s)

Show full item record