Serum non-cholesterol sterols and cholesterol metabolism in childhood and adolescence

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Gylling , H , Korhonen , M , Mutanen , A , Nissinen , M J , Pakarinen , M & Simonen , P 2018 , ' Serum non-cholesterol sterols and cholesterol metabolism in childhood and adolescence ' , Atherosclerosis , vol. 278 , pp. 91-96 . https://doi.org/10.1016/j.atherosclerosis.2018.09.017

Title: Serum non-cholesterol sterols and cholesterol metabolism in childhood and adolescence
Author: Gylling, Helena; Korhonen, Matilda; Mutanen, Annika; Nissinen, Markku J.; Pakarinen, Mikko; Simonen, Piia
Other contributor: University of Helsinki, Clinicum
University of Helsinki, HUS Heart and Lung Center
University of Helsinki, Children's Hospital
University of Helsinki, Gastroenterologian yksikkö
University of Helsinki, Lastenkirurgian yksikkö
University of Helsinki, Department of Medicine








Date: 2018-11
Language: eng
Number of pages: 6
Belongs to series: Atherosclerosis
ISSN: 0021-9150
DOI: https://doi.org/10.1016/j.atherosclerosis.2018.09.017
URI: http://hdl.handle.net/10138/307719
Abstract: Background and aims: The profile of cholesterol metabolism, i.e., high absorption vs. high synthesis, may have a role in the development of atherosclerosis, the early lesions of which can be present already in childhood. Since there is no information on cholesterol metabolism in children from birth to adolescence, we evaluated cholesterol metabolism in 0-15 year-old children and adolescents without dyslipidemia. Methods: The study population consisted of 96 children (39 girls, 57 boys) divided into age groups Results: Serum non-cholesterol sterol ratios to cholesterol did not differ between gender. Cholesterol precursors squalene, cholestenol, and desmosterol were higher in the Conclusions: Serum non-cholesterol sterols had different individual profiles by age in childhood and adolescence. From 1 to 10 years of age, cholesterol absorption prevailed cholesterol synthesis. This novel finding emphasizes the importance of dietary aspects related to cardiovascular risk even from early childhood.
Subject: Children
Cholesterol
Cholesterol absorption
Cholesterol synthesis
Desmosterol
Lathosterol
CARDIOVASCULAR RISK
PLANT STEROLS
ABSORPTION
CHILDREN
CHOLESTANOL
PRECURSORS
SQUALENE
INFANTS
NPC1L1
3123 Gynaecology and paediatrics
3121 General medicine, internal medicine and other clinical medicine
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