Differences and overlap in plasma protein expression during colorectal cancer progression

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Holm , M , Joenväärä , S , Saraswat , M , Tohmola , T , Ristimäki , A , Renkonen , R & Haglund , C 2019 , ' Differences and overlap in plasma protein expression during colorectal cancer progression ' , Translational Medicine Communications , vol. 4 , no. 1 , 14 . https://doi.org/10.1186/s41231-019-0044-5

Title: Differences and overlap in plasma protein expression during colorectal cancer progression
Author: Holm, Matilda; Joenväärä, Sakari; Saraswat, Mayank; Tohmola, Tiialotta; Ristimäki, Ari; Renkonen, Risto; Haglund, Caj
Contributor organization: Department of Surgery
Faculty of Medicine
University of Helsinki
Department of Pathology
CAN-PRO - Translational Cancer Medicine Program
Research Programs Unit
ATG - Applied Tumor Genomics
HUSLAB
Transplantation Laboratory
Medicum
Biosciences
Faculty of Biological and Environmental Sciences
University Management
Gastrointestinal tumorigenesis
Infection Biology Research Program
Risto Renkonen / Principal Investigator
HUS Abdominal Center
II kirurgian klinikka
Date: 2019-08-05
Language: eng
Number of pages: 12
Belongs to series: Translational Medicine Communications
ISSN: 2396-832X
DOI: https://doi.org/10.1186/s41231-019-0044-5
URI: http://hdl.handle.net/10138/307751
Abstract: Colorectal cancer (CRC) is the third most common cancer worldwide, and its incidence is expected to increase to over 2.2 million new cases in 2030. Stage II CRC is classified as localized disease, while stage III CRC has spread to regional lymph nodes. The 5-year survival rate is over 80% for patients with stage II CRC, but less than 60% for patients with stage III CRC. Proteins, especially plasma proteins that are detectable in easily obtained blood samples, that differ between stage II and III CRC could be useful for predicting and monitoring disease progression. CRC displays differences depending on primary tumor location (right colon, left colon, or rectum), and how plasma protein expression changes during CRC progression from stage II to III depending on primary tumor location is not well-characterized.
Subject: 3111 Biomedicine
Peer reviewed: Yes
Rights: cc_by
Usage restriction: openAccess
Self-archived version: publishedVersion


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