Surface Modification of Acetaminophen Particles by Atomic Layer Deposition

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http://hdl.handle.net/10138/307765

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Kääriäinen , T O , Kemell , M L , Vehkamäki , M J , Kääriäinen , M-L , Correia , A , Almeida Santos , H , Marques dos Santos Bimbo , L M , Hirvonen , J T , Hoppu , P , George , S M , Cameron , D C , Ritala , M K & Leskelä , M A 2017 , ' Surface Modification of Acetaminophen Particles by Atomic Layer Deposition ' , International Journal of Pharmaceutics , vol. 525 , no. 1 , pp. 160–174 . https://doi.org/10.1016/j.ijpharm.2017.04.031

Title: Surface Modification of Acetaminophen Particles by Atomic Layer Deposition
Author: Kääriäinen, Tommi Olavi; Kemell, Marianna Leena; Vehkamäki, Marko Juhani; Kääriäinen, Marja-Leena; Correia, Alexandra; Almeida Santos, Helder; Marques dos Santos Bimbo, Luis Maria; Hirvonen, Jouni Tapio; Hoppu, Pekka; George, Steven M.; Cameron, David C.; Ritala, Mikko Kalervo; Leskelä, Markku Antero
Contributor: University of Helsinki, Department of Chemistry
University of Helsinki, Department of Chemistry
University of Helsinki, Department of Chemistry
University of Helsinki, Nanomedicines and Biomedical Engineering
University of Helsinki, Faculty of Pharmacy
University of Helsinki, Faculty of Pharmacy
University of Helsinki, Faculty of Pharmacy
University of Helsinki, Department of Chemistry
University of Helsinki, Department of Chemistry
Date: 2017-06-15
Number of pages: 15
Belongs to series: International Journal of Pharmaceutics
ISSN: 0378-5173
URI: http://hdl.handle.net/10138/307765
Abstract: Organic solid pharmaceutical powders are used for the preparation of various drug dosage forms. Primary particles in powder form undergo several processing steps first in pharmaceutical formulations followed by pharmaceutical manufacturing to final dosage form of a drug. These unit operations involve both handling of powders in aqueous or solvent solutions and drying. There will be a probable rise for a demand for the different unit operations in the requirements of protecting the active pharmaceutical ingredient or challenges in powder handling. Besides pharmaceutical manufacturing, there are many biological interfaces where control of surface characteristics of pharmaceutical powders can improve the therapeutic response and bioavailability. In this work, we have modified acetaminophen particles with atomic layer deposition (ALD) by conformal nanometer scale coatings in a one-step coating process. According to the results, ALD comprising common chemistries for Al2O3, TiO2 and ZnO is shown to be a promising coating method for solid pharmaceutical powders. Acetaminophen does not undergo degradation during the ALD coating and maintains its stable polymorphic structure. The nanometer scale ALD coating can sustain the drug release. ALD oxide coated acetaminophen particles show different cytocompatibility assessed in in vitro intestinal Caco-2 cells.
Subject: 116 Chemical sciences
317 Pharmacy
Atomic layer deposition
Acetaminophen
Drug release
Cytocombatibility
Drug delivery system
SOLID-STATE CHARACTERIZATION
FLUIDIZED-BED REACTOR
TITANIUM ISOPROPOXIDE
DRUG-DELIVERY
PHYSICAL STABILITY
AL2O3 FILMS
PARACETAMOL
GROWTH
NANOPARTICLES
POLYMORPHS
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