Liquorice ingestion attenuates vasodilatation via exogenous nitric oxide donor but not via β2-adrenoceptor stimulation

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http://hdl.handle.net/10138/307789

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Hautaniemi , E J , Tikkakoski , A J , Eräranta , A , Kähönen , M , Hämäläinen , E , Turpeinen , U , Huhtala , H , Mustonen , J & Pörsti , I H 2019 , ' Liquorice ingestion attenuates vasodilatation via exogenous nitric oxide donor but not via β2-adrenoceptor stimulation ' , PLoS One , vol. 14 , no. 10 , e0223654 . https://doi.org/10.1371/journal.pone.0223654

Title: Liquorice ingestion attenuates vasodilatation via exogenous nitric oxide donor but not via β2-adrenoceptor stimulation
Author: Hautaniemi, Elina J.; Tikkakoski, Antti J.; Eräranta, Arttu; Kähönen, Mika; Hämäläinen, Esa; Turpeinen, Ursula; Huhtala, Heini; Mustonen, Jukka; Pörsti, Ilkka H.
Contributor: University of Helsinki, Medicum
University of Helsinki, Department of Diagnostics and Therapeutics
Date: 2019-10-18
Language: eng
Number of pages: 19
Belongs to series: PLoS One
ISSN: 1932-6203
URI: http://hdl.handle.net/10138/307789
Abstract: We examined the effect of liquorice ingestion on haemodynamic responses to exogenous nitric oxide donor (nitroglycerin) and β2-adrenoceptor agonist (salbutamol), and 11β-hydroxysteroid dehydrogenase activity, in 21 volunteers and 21 reference subjects. Haemodynamic data was captured before and after sublingual nitroglycerin (0.25 mg) and inhaled salbutamol (400 μg) during orthostatic challenge utilising radial pulse wave analysis and whole-body impedance cardiography. The recordings were performed at baseline and following two weeks of liquorice intake (290–370 mg/d glycyrrhizin). Urinary cortisone and cortisol metabolites were examined. Liquorice intake elevated aortic systolic and diastolic blood pressure and systemic vascular resistance when compared with the reference group. Following research drug administration the liquorice-induced increase in systemic vascular resistance was observed in the presence of nitroglycerin (p
Subject: 3111 Biomedicine
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