Expression of VEGFA-regulating miRNAs and mortality in wet AMD

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Blasiak , J , Watala , C , Tuuminen , R , Kivinen , N , Koskela , A , Uusitalo-Jarvinen , H , Tuulonen , A , Winiarczyk , M , Mackiewicz , J , Zmorzynski , S , Filip , A & Kaarniranta , K 2019 , ' Expression of VEGFA-regulating miRNAs and mortality in wet AMD ' , Journal of Cellular and Molecular Medicine , vol. 23 , no. 12 , pp. 8464-8471 . https://doi.org/10.1111/jcmm.14731

Title: Expression of VEGFA-regulating miRNAs and mortality in wet AMD
Author: Blasiak, Janusz; Watala, Cezary; Tuuminen, Raimo; Kivinen, Niko; Koskela, Ali; Uusitalo-Jarvinen, Hannele; Tuulonen, Anja; Winiarczyk, Mateusz; Mackiewicz, Jerzy; Zmorzynski, Szymon; Filip, Agata; Kaarniranta, Kai
Contributor: University of Helsinki, Medicum
Date: 2019-12
Language: eng
Number of pages: 8
Belongs to series: Journal of Cellular and Molecular Medicine
ISSN: 1582-1838
URI: http://hdl.handle.net/10138/307818
Abstract: MicroRNAs (miRNAs) regulate gene expression; many of them act in the retinal pigment epithelium (RPE), and RPE degeneration is known to be a critical factor in age-related macular degeneration (AMD). Repeated injections with anti-VEGFA (vascular endothelial growth factor A) are the only effective therapy in wet AMD. We investigated the correlation between the expression of 18 miRNAs involved in the regulation of the VEGFA gene in serum of 76 wet AMD patients and 70 controls. Efficacy of anti-VEGFA treatment was evaluated by counting the number of injections delivered up to 12 years. In addition, we compared the relative numbers of deaths in patient with AMD and control groups. We observed a decreased expression of miR-34-5p, miR-126-3p, miR-145-5p and miR-205-5p in wet AMD patients as compared with controls. These miRNAs are involved in the regulation of angiogenesis, cytoprotection and protein clearance. No miRNA was significantly correlated with the treatment outcome. Wet AMD patients had greater mortality than controls, and their survival was inversely associated with the number of anti-VEGFA injections per year. No association was observed between miRNA expression and mortality. Our study emphasizes the need to clarify the role of miRNA regulation in AMD pathogenesis.
Subject: age-related macular degeneration
AMD
anti-VEGFA injection
miRNA
mortality
wet AMD therapy
MACULAR DEGENERATION PATIENTS
INFLAMMATORY RESPONSE
ENDOTHELIAL-CELLS
GENE-EXPRESSION
AGE
RISK
MICRORNA-126
ANGIOGENESIS
PROTEOLYSIS
GUIDELINES
1182 Biochemistry, cell and molecular biology
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