Single-calibrant quantification of seized synthetic opioids by liquid chromatography-chemiluminescence nitrogen detection

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Rasanen , I , Kyber , M , Szilvay , I , Rintatalo , J & Ojanperä , I 2019 , ' Single-calibrant quantification of seized synthetic opioids by liquid chromatography-chemiluminescence nitrogen detection ' , Forensic Science International , vol. 305 , 110001 . https://doi.org/10.1016/j.forsciint.2019.110001

Title: Single-calibrant quantification of seized synthetic opioids by liquid chromatography-chemiluminescence nitrogen detection
Author: Rasanen, Ilpo; Kyber, Marianne; Szilvay, Ilmari; Rintatalo, Janne; Ojanperä, Ilkka
Contributor: University of Helsinki, Department of Forensic Medicine
Date: 2019-12
Language: eng
Number of pages: 3
Belongs to series: Forensic Science International
ISSN: 0379-0738
URI: http://hdl.handle.net/10138/307881
Abstract: Drug seizures involving a wide variety of emerging new psychoactive substances (NPS) call for new approaches for instant quantification and valuation. Liquid chromatography-chemiluminescence nitrogen detection (LC-CLND) was used in the quantification of opioids with a single secondary standard (caffeine), utilizing the detector's equimolar response to nitrogen. The mean N-equimolarity of CLND for ten fentanyl derivatives and U-47700 by the present LC-CLND method was 96.4% (range 91-101%). The furanylfentanyl samples consisted of 112 powdery samples with a mean (median, range) hydrochloride purity of 13% (4.9%, 0.08-100%). The purity distribution of the furanylfentanyl samples was distinctly bipartite, showing only lower than 9% (NI = 98) and higher than 60% (N=14) purities. The carfentanil samples consisted of eight brownish sticky samples with a mean (median, range) hydrochloride purity of 0.064% (0.063%, 0.052-0.092%). The U-47700 samples consisted of seven powdery samples with a mean (median, range) hydrochloride purity of 89.0% (100%, 51-100%). The present application to synthetic opioid analysis widens the scope of the established LC-CLND method, previously found useful for single-calibrant quantification of stimulant/hallucinogenic and cannabinoid type of NPS. (C) 2019 Elsevier B.V. All rights reserved.
Subject: New psychoactive substances
Drug seizure
Fentanyl derivative
Furanylfentanyl
Chemiluminescence nitrogen detection
Reference standard
DRUGS
319 Forensic science and other medical sciences
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