Single-calibrant quantification of seized synthetic opioids by liquid chromatography-chemiluminescence nitrogen detection

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dc.contributor.author Rasanen, Ilpo
dc.contributor.author Kyber, Marianne
dc.contributor.author Szilvay, Ilmari
dc.contributor.author Rintatalo, Janne
dc.contributor.author Ojanperä, Ilkka
dc.date.accessioned 2019-12-04T10:42:02Z
dc.date.available 2019-12-04T10:42:02Z
dc.date.issued 2019-12
dc.identifier.citation Rasanen , I , Kyber , M , Szilvay , I , Rintatalo , J & Ojanperä , I 2019 , ' Single-calibrant quantification of seized synthetic opioids by liquid chromatography-chemiluminescence nitrogen detection ' , Forensic Science International , vol. 305 , 110001 . https://doi.org/10.1016/j.forsciint.2019.110001
dc.identifier.other PURE: 127621470
dc.identifier.other PURE UUID: 55fb2b03-eaa9-43ef-82c3-3874d4dbb336
dc.identifier.other RIS: urn:3D7A84F51DF54AEC75B832BB59C4EDC3
dc.identifier.other ORCID: /0000-0001-5790-1473/work/65669059
dc.identifier.other WOS: 000500765300012
dc.identifier.uri http://hdl.handle.net/10138/307881
dc.description.abstract Drug seizures involving a wide variety of emerging new psychoactive substances (NPS) call for new approaches for instant quantification and valuation. Liquid chromatography-chemiluminescence nitrogen detection (LC-CLND) was used in the quantification of opioids with a single secondary standard (caffeine), utilizing the detector's equimolar response to nitrogen. The mean N-equimolarity of CLND for ten fentanyl derivatives and U-47700 by the present LC-CLND method was 96.4% (range 91-101%). The furanylfentanyl samples consisted of 112 powdery samples with a mean (median, range) hydrochloride purity of 13% (4.9%, 0.08-100%). The purity distribution of the furanylfentanyl samples was distinctly bipartite, showing only lower than 9% (NI = 98) and higher than 60% (N=14) purities. The carfentanil samples consisted of eight brownish sticky samples with a mean (median, range) hydrochloride purity of 0.064% (0.063%, 0.052-0.092%). The U-47700 samples consisted of seven powdery samples with a mean (median, range) hydrochloride purity of 89.0% (100%, 51-100%). The present application to synthetic opioid analysis widens the scope of the established LC-CLND method, previously found useful for single-calibrant quantification of stimulant/hallucinogenic and cannabinoid type of NPS. (C) 2019 Elsevier B.V. All rights reserved. en
dc.format.extent 3
dc.language.iso eng
dc.relation.ispartof Forensic Science International
dc.rights cc_by_nc_nd
dc.rights.uri info:eu-repo/semantics/openAccess
dc.subject New psychoactive substances
dc.subject Drug seizure
dc.subject Fentanyl derivative
dc.subject Furanylfentanyl
dc.subject Chemiluminescence nitrogen detection
dc.subject Reference standard
dc.subject DRUGS
dc.subject 319 Forensic science and other medical sciences
dc.title Single-calibrant quantification of seized synthetic opioids by liquid chromatography-chemiluminescence nitrogen detection en
dc.type Article
dc.contributor.organization Department of Forensic Medicine
dc.contributor.organization Forensic Medicine
dc.contributor.organization University of Helsinki
dc.description.reviewstatus Peer reviewed
dc.relation.doi https://doi.org/10.1016/j.forsciint.2019.110001
dc.relation.issn 0379-0738
dc.rights.accesslevel openAccess
dc.type.version acceptedVersion
dc.type.version publishedVersion

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