Paired associative stimulation improves hand function after nontraumatic spinal cord injury: a case series

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http://hdl.handle.net/10138/307924

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Tolmacheva , A , Savolainen , S , Kirveskari , E , Brandstack , N , Mäkelä , J P & Shulga , A 2019 , ' Paired associative stimulation improves hand function after nontraumatic spinal cord injury: a case series ' , Clinical neurophysiology practice , vol. 4 , pp. 178–183 . https://doi.org/10.1016/j.cnp.2019.07.002

Titel: Paired associative stimulation improves hand function after nontraumatic spinal cord injury: a case series
Författare: Tolmacheva, Aleksandra; Savolainen, Sarianna; Kirveskari, Erika; Brandstack, Nina; Mäkelä, Jyrki P.; Shulga, Anastasia
Upphovmannens organisation: HUS Medical Imaging Center
BioMag Laboratory
University of Helsinki
Department of Neurosciences
Kliinisen neurofysiologian yksikkö
Department of Diagnostics and Therapeutics
HUS Neurocenter
Neurologian yksikkö
Datum: 2019-08-13
Språk: eng
Sidantal: 6
Tillhör serie: Clinical neurophysiology practice
ISSN: 2467-981X
DOI: https://doi.org/10.1016/j.cnp.2019.07.002
Permanenta länken (URI): http://hdl.handle.net/10138/307924
Abstrakt: Objectives Long-term paired associative stimulation (PAS) is a non-invasive combination of transcranial magnetic stimulation and peripheral nerve stimulation and leads to improved hand motor function in individuals with incomplete traumatic tetraplegia. Spinal cord injuries (SCIs) can also be induced by neurological diseases. We tested a similar long-term PAS approach in patients with nontraumatic neurological SCI. Methods In this case series five patients with nontraumatic tetraplegia received PAS to the weaker upper limb 3 to 5 times per week for 6 weeks. Patients were evaluated with manual muscle testing (MMT) before and immediately after therapy and at the 1- and 6-month follow ups. Patients were also evaluated for spasticity, hand mechanical and digital dynamometry, pinch, and Box and Blocks tests. Results All patients had improved MMT values at all post-PAS evaluations. The mean±standard error MMT increase was 1.44±0.37 points (p=0.043) immediately after PAS, 1.57±0.4 points (p=0.043) at the 1-month follow-up, and 1.71±0.47 points (p=0.043) at the 6-month follow up. The pinch, digital dynamometry values, and Box and Blocks test results also improved in all patients. Conclusions Long-term PAS may be a safe and effective treatment for improving hand function in patients with nontraumatic tetraplegia. Significance This is the first report demonstrating the therapeutic potential of PAS for neurological SCI.
Subject: 3112 Neurosciences
TMS
Rehabilitation
Plasticity
Spinal Cord
Paired Associative Stimulation
Spinal Cord Injury
INDUCTION
Spinal cord injury
RECOVERY
PRIORITIES
MOTOR CORTEX
BRAIN
PLASTICITY
Referentgranskad: Ja
Licens: cc_by_nc_nd
Användningsbegränsning: openAccess
Parallelpublicerad version: publishedVersion


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